1. The Potential Risk to Humans of Amyloids in Animals --;I. Host Range and Pathogenesis --;2. Bovine Spongiform Encephalopathy Distribution and Update on Some Transmission and Decontamination Studies --;3. Preliminary Observations on the Pathogenesis of Experimental Bovine Spongiform Encephalopathy --;4. Recent Observations on the Epidemiology of Bovine Spongiform Encephalopathy --;II. Transmission and Pathogenesis of Spongiform Encephalopathies --;5. Scrapie: Studies on Vertical and Horizontal Transmission --;6. Transmission of Sheep and Goat Strains of Scrapie from Experimentally Infected Cattle to Hamsters and Mice --;7. Experimental Transmission of Scrapie to Cattle --;8. An Assessment of Transmissible Mink Encephalopathy as an Indicator of Bovine Scrapie in U.S. Cattle --;9. Experimental Infections of Cattle and Mink with the Agents of Transmissible Mink Encephalopathy, Scrapie, and Bovine Spongiform Encephalopathy --;10. BSE-Free Status: What Does It Mean? --;11. Differing Neurohistologic Images of Scrapie, Transmissible Mink Encephalopathy, and Chronic Wasting Disease of Mule Deer and Elk --;12. Analysis of Risk Factors and Active Surveillance for BSE in Argentina --;13. Speculations on the Origin of BSE and the Epidemiology of CJD --;III. Biochemistry: Protein Chemistry, Molecular Biology, and Molecular Genetics of the Spongiform Encephalopathies --;14. Structure and Biologic Characteristics of Prion Protein (Scrapie Amyloid): Implications for the Safety of Naturally Derived Biologics --;15. Prion Strains and Neuromuscular Disease in PrP Transgenic Mice --;16. Deciphering Prion Diseases with Transgenic Mice --;17. Posttranslational Modifications and Conformational Changes of PrPSc and Their Relationship to Infectivity --;18. Amyloidosis: The Key to the Epidemiology and Pathogenesis of Transmissible Spongiform Encephalopathies --;19. Effect of Amphotericin B on Different Experimental Strains of Spongiform Encephalopathy Agents --;IV. Pathogenesis, Molecular Biology and Genetics, and Immunohistochemistry --;20. Genetics of Human Spongiform Encephalopathies: Current Status --;21. PrP Allelic Variants Associated with Natural Scrapie --;22. The Formation of Scrapie-Associated Prion Protein In Vitro --;23. Proteinase K-Resistant Prion Protein Detection in Animal Tissues and In Vitro --;24. Elimination of Scrapie-Agent Infectivity in Naturally Derived Biologics --;25. Cellular and Scrapie Prion Protein Immunolocalization and In Vitro Amyloid Formation --;V. Public Health Considerations of Human and Animal Spongiform Encephalopathies --;26. Real and Theoretical Threats to Human Health Posed by the Epidemic of Bovine Spongiform Encephalopathy --;27. Incidence of Creutzfeldt-Jakob Disease in the European Community --;28. Problems in the Evaluation of Theoretical Risks for Humans to Become Infected with BSE-Contaminated Bovine-Derived Pharmaceutical Products --;29. Evaluation of BSE Risk Factors Among European Countries --;Author Index.
SUMMARY OR ABSTRACT
Text of Note
This volume contains the proceedings of the Sixth International Workshop on Bovine Spongiform Encephalopathy: the BSE Dilemma, held in Williamsburg, Virginia between February 27 and March 1 1994. The papers look at the pathogenesis, transmission and biochemistry of the disease.