عنوان

Handbook of immunological properties of nanomaterials

(Number (ISBN

129913310X

(Number (ISBN

1628702273

(Number (ISBN

9781299133105

(Number (ISBN

9781628702279

(Number (ISBN

9789814390262

(Number (ISBN

9814390267

Number

b547371

Title Proper

Handbook of immunological properties of nanomaterials

General Material Designation

[Book]

First Statement of Responsibility

editors, Marina A. Doborovolskaia, Scott E. McNeil.

Place of Publication, Distribution, etc.

Hackensack, N.J.

Name of Publisher, Distributor, etc.

World Scientific

Date of Publication, Distribution, etc.

2013

Specific Material Designation and Extent of Item

(721 p.).

Series Title

Frontiers in nanobiomedical research, v. 1

Text of Note

Description based upon print version of record.;Chapter 5 Surface Adsorbates on Nanomaterials and Their Possible Roles in Host Inflammatory and Toxicological Processing Clinton F. Jones, David G. Castner, and David W. Grainger

Text of Note

Preface; List of Contributors; Chapter 1 Immunological Properties of Engineered Nanomaterials: An Introduction Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. Interaction with Blood Components; 2.1. Hemolysis; 2.2. Coagulation; 2.3. Complement activation; 3. Nanoparticle Uptake by Phagocytic Cells; 4. Immunogenicity; 4.1. Inflammation; 4.2. Antigenicity; 4.3. Adjuvant properties; 5. Immunosuppression; 6. Designing Immunotoxicity Studies; 7. Future Directions; References Chapter 2 Importance of Physicochemical Characterization Prior to Immunological Studies Jeffrey D. Clogston and Anil K. Patri1. Introduction; 2. Key Parameters that Influence Nanomaterial Immunological Properties; 3. Instrumentation for Physicochemical Characterization; 4. Methodologies for Nanomaterial Separation; 5. A Closer Look; 5.1. Dynamic light scattering; 5.1.1. Additional considerations for DLS measurements; 5.2. Zeta potential; 6. Summary; References; Chapter 3 Impact of Nanoparticle Sterilization on Analytical Characterization Nanda Subbarao; 1. Introduction 2. Why Is Sterilization a Challenge for Nanotherapeutics?3. Previous Studies Reviewing the Effects of Various Sterilization Procedures on Nanomaterials; 4. Available Methods for Sterilization; 4.1. Autoclaving; 4.1.1. Impact on NT analytics; 4.2. Filtration; 4.2.1. Impact on NT analytics; 4.3. Gamma irradiation; 4.3.1. Gamma irradiation of SLNs; 4.3.2. Gamma irradiation and liposomes; 4.3.3. Mitigating the effects of gamma irradiation; 4.3.4. Gamma irradiation remains a method of choice for NTs; 4.3.5. Impact on NT analytics; 4.4. Gaseous ethylene oxide; 4.4.1. Impact on NT analytics 4.5. High hydrostatic pressure sterilization4.6. Formaldehyde; 5. Comparison of Different Methods for Sterilization; 6. Impact on Nanotherapeutic Analytics; 7. Conclusions; References; Chapter 4 Endotoxin and Engineered Nanomaterials Marina A. Dobrovolskaia and Scott E. McNeil; 1. Introduction; 2. What Endotoxin Is and Why It Is Important to Study in Nanoformulations; 3. Methods Used for Endotoxin Detection and Quantification; 3.1. Traditional methods; 3.2. Alternative methods; 3.2.1. Gel-staining-based methods; 3.2.2. Ligand binding-based methods; 3.2.3. Mass spectrometry-based methods 3.2.4. Macrophage activation test4. Estimating Endotoxin in Nanoformulations; 4.1. Nanoparticle interference with traditional methods; 4.2. Evaluation of interference; 4.3. How to choose an appropriate LAL format; 4.4. Application of non-traditional methods; 4.4.1. Gel-based assay; 4.4.2. Western blot-based assay; 5. Use of Traditional Endotoxin-Neutralizing Reagents in Nanoparticle Research; 5.1. Case study 1; 5.2. Case study 2; 6. Minimizing Contamination and Interference; 7. Purification and Depyrogenation of Nanoformulations; 8. Conclusions and Future Directions; References

Text of Note

Suitable for students, scientific consultants, reviewers and policy makers, this title provides a comprehensive overview of literature, methodologies, translational and regulatory considerations in the field of nanoimmunotoxicology.

Nanostructured materials -- Handbooks, manuals, etc.

Nanostructured materials -- Health aspects.

Nanotechnology -- Health aspects.

Class number

Book number

editors, Marina A. Doborovolskaia, Scott E. McNeil.

Marina A Doborovolskaia

Marina A Dobrovolskaia

Scott E McNeil

Electronic name

[Book]

Y