Chapman & Hall/CRC mathematical and computational biology series
CONTENTS NOTE
Text of Note
Fundamentals Introduction Biological BasicsThe Cell-an Introduction Cell Division and Growth Basics of MetabolismReplication, Transcription, and TranslationFundamentals of Mathematical Modeling Definition-Overview of Different Model Classes Basics of Reaction Engineering Stochastic Description Deterministic Modeling Qualitative Modeling and AnalysisModeling on the Level of Single Cells-the Population Balance Data-Driven Modeling ThermodynamicsModel Calibration and Experimental Design RegressionModel and Parameter AccuracyDynamic SystemsIdentifiability of Dynamic SystemsModeling of Cellular ProcessesEnzymatic Conversion Fundamentals of Enzyme Kinetics Models for Allosteric Enzymes Influence of EffectorsThe Hill Equation Multi Substrate Kinetics Transport Processes The Wegscheider Condition Alternative Kinetic Approaches Thermodynamic of a Single ReactionPolymerization Processes Macroscopic View Microscopic View Influence of Regulatory Proteins (Transcription Factors, Repressors)Interaction of Several RegulatorsReplicationSignal Transduction and Genetically Regulated Systems Simple Schemes of Signal Transduction Oscillating Systems Genetically Regulated NetworksSpatial Gradients by Signal Transduction Analysis of Signaling Pathways by HeinrichAnalysis of Modules and MotifsGeneral Methods of Model AnalysisAnalysis of Time Hierarchies Sensitivity AnalysisRobustness in Stoichiometric Networks Metabolic Control AnalysisBiochemical Systems TheoryStructured Kinetic Modeling Model Reduction for Signal ProteinsAspects of Control Theory Observability Monotone Systems Integral Feedback Robust Control Motifs in Cellular Networks Feed-Forward Loop (FFL) FFLs in Metabolic Networks FFL in Signaling Systems: Two-component Signal TransductionFurther Signaling MotifsAnalysis of Cellular Networks Metabolic Engineering Reconstruction of Metabolic Network Tasks and Problem Definition Subspaces of Matrix N Methods to Determine Flux DistributionsStrain OptimizationTopological Characteristics Network Measures Topological Overlap Formation of Scale Free NetworksAppendixIndexExercises and Bibliography appear at the end of each chapter.