عنوان

Biochemical Pharmacology of Blood and Bloodforming Organs

(Number (ISBN

3642758657

(Number (ISBN

9783642758652

Number

b546147

Title Proper

Biochemical Pharmacology of Blood and Bloodforming Organs

General Material Designation

[Book]

First Statement of Responsibility

edited by James W. Fisher.

Place of Publication, Distribution, etc.

Berlin, Heidelberg

Name of Publisher, Distributor, etc.

Springer Berlin Heidelberg

Date of Publication, Distribution, etc.

1992

Specific Material Designation and Extent of Item

(xvi, 587 pages 64 illustrations)

Series Title

Handbook of experimental pharmacology, 101.

Text of Note

1 Introduction --;2 Fundamental Control of Hematopoiesis --;A. Introduction --;B. Hierarchical Organization of Hematopoietic Cells --;C. Assay and Characterization of In Vitro Clonogenic Cells --;D. Use of In Vitro Clonogenic Cell Assays --;E. Newer Assays for More Primitive Cells --;F. Regulatory Mechanisms --;G. Future Outlook --;References --;3 Kidney Regulation of Erythropoietin Production --;A. Introduction --;B. Model for the Control of Erythropoietin Production --;C. Hypoxia and Erythropoietin Production --;D. Adenosine and Erythropoietin Production --;References --;4 The Mechanism of Action of Erythropoietin: Erythroid Cell Response --;A. Introduction --;B. Model Systems for Studying the Interaction of Erythropoietin with Erythroid Progenitor Cells --;C. Interaction of Other Growth and Development Factors with Erythroid Progenitor Cells --;D. The Erythroid Differentiation Program --;E. Signal Transduction in Erythroid Progenitor Cells --;F. Erythropoietin as a Competence or Progression Factor --;G. Conclusion --;References --;5 The Arachidonic Acid Cascade and Erythropoiesis --;A. Introduction --;B. Evidence for the Roles of Arachidonic Acid Metabolism in Erythropoiesis --;C. Future Directions for Research --;References --;6 Iron Deficiency and Megaloblastic Anemias --;A. Iron-Deficiency Anemia --;B. Megaloblastic Anemias --;References --;7 Erythropoietin in the Anemia of End-Stage Renal Disease --;A. Assay of Erythropoietin --;B. Pathogenesis of the Anemia of Chronic Renal Failure --;C. Kidney Production of Erythropoietin --;D. Erythropoietin in Therapy of Renal Anemia --;E. Conclusions --;References --;8 Humoral Control of Thrombocytopoiesis --;A. Introduction --;B. Model for Megakaryocytopoiesis --;C. Controlling Factors --;D. Other Factors Affecting Thrombocytopoiesis --;E. Clinical Aspects of Thrombopoietin --;F. Future of Thrombopoietin --;References --;9 Arachidonic Acid Metabolism Platelets and Thromboembolic Disease --;A. Arachidonic Acid Metabolism --;B. Thromboembolic Disease --;C. Concluding Comments --;References --;10 Chemical Agents That Inhibit Platelet Aggregation --;A. Introduction --;B. Platelet Physiology --;C. Platelet Structure --;D. Platelet Involvement in Thrombosis --;E. Platelet Responses --;F. Inhibition of Platelet Aggregation --;G. Conclusions --;References --;11 Anticoagulants, Antithrombotic and Thrombolytic Agents --;A. Anticoagulants --;B. Thrombolytic Therapy --;C. Antithrombotic Therapy --;References --;12 Granulocyte-Macrophage Growth Factors --;A. Introduction --;B. Historical Background --;C. Growth Factors --;D. Other Interleukins --;E. Inhibitors --;F. Cellular Production and Networking --;G. Microenvironment --;H. Conclusions --;References --;13 Chemical Agents Which Suppress Myelopoiesis: Agranulocytosis and Leukemia --;A. Introduction --;B. Normal Marrow Cell Kinetics --;C. Pathophysiologic Mechanisms for Drug-Induced Neutropenia --;D. Neutropenia Associated with Cytotoxic Chemotherapeutic Agents --;E. Drug-Induced Myeloid Suppression --;F. Idiosyncratic Neutropenias --;G. Pseudoneutropenia --;H. Secondary Leukemia --;J. Conclusions --;References --;14 Drugs Useful in the Chemotherapy of the Acute Leukemias --;A. Introduction --;B. Antimetabolites --;C. Drugs that Intercalate in DNA --;D. Podophyllotoxin Derivatives --;E. Vinca Alkaloids --;F. Alkylating/DNA Binding Agents --;G. Adrenal Glucocorticoids --;H. Enzymes --;J. Multidrug Resistance --;References.

Text of Note

The subject of this volume is to review chemical agents which affect blood and blood-forming organs. Significant ad- vances made over the past several years in the purification of several hematopoietic growth factors, such as erythro- poietin and colony stimulating factor; the availability of several other growth factors, such as the interleukins which are important in regulating the production of red blood cells, leukocytes, megakaryocytes and platelets are discus- sed. Numerous toxic chemical substances are being produced in our environment which people are exposed todaily causing a suppression of erythropoiesis, myelopoiesis and megakaryo- cytopoiesis. Attempts to evaluate both the therapeutic role of some of the newer growth factors, such as erythropoietin in the anemia of end stage disease, as well as colony stimu- lating factors in somehematopoietic abnormalities are also covered in this volume. In addition, numerous chemical fac- tors in our environment which suppress major hematopoietic lineages stimulated by erythropoietin, macrophage colony stimulating factor, granulocyte colony stimulating factor, interleukin 1-alpha, 1-beta, 2,3,4,5,6, and 7 are also in- cluded. In addition, chapters on the use of erythropoietin in the treatment of anemia of end stage renal disease can provide the practicing hematologist and nephrologist with updated information on the use of erythropoietin for this disease. The book includes chapters on the fundamental con- trol of hematopoiesis and other mechanisms of action of erythropoietin, and finally an up-to-date overview of the chemotherapy of leukemia. This book will prove useful to in- vestigators in the fields of pharmacology, physiology, nephrology, urology, hematology, pathology, endocrinology, biochemistry, and molecular and cell biology.

Human physiology.

Medicine.

Toxicology.

Class number

Book number

edited by James W. Fisher.

James W Fisher

Electronic name

[Book]

Y