1 Introduction --;1.1 Background --;1.2 Systemic versus Local and Regional Hyperthermia --;1.3 Conceptual Approaches to the Therapeutic Use of WBH --;1.4 Summary --;2 Hyperthermia and the Immune System --;2.1 Introduction --;2.2 In Vitro Studies of Hyperthermia and Immune Effector Cells --;2.3 In Vivo Studies: The Abscopal Response and Metastasis --;2.4 Clinical Hyperthermia and the Abscopal Response --;2.5 Clinical WBH and the Immune Response --;2.6 Conclusions --;3 WBH and Ionizing Irradiation --;3.1 Background --;3.2 Potential Advantages of WBH Compared to Local Hyperthermia --;3.3 The Importance of Treatment Temperatures Used in Preclinical Studies --;3.4 Possibly Controllable Clinical Treatment Variables --;3.5 Clinical Investigations Combining WBH and Ionizing Irradiation --;3.6 Summary --;4 WBH and Chemotherapy --;4.1 Introduction --;4.2 Potential Mechanisms of Thermal Chemosensitization --;4.3 Factors Which May Modify Thermal Chemosensitization --;4.4 Therapeutic Index --;4.5 Probable Thermal Sensitizing Agents --;4.6 Future Directions for Preclinical Research --;4.7 Clinical WBH Studies --;5 Clinical and Biophysical Aspects of Systemic Hyperthermia --;5.1 Thermal Regulation and WBH Methodologies --;5.2 Monitoring Body Site Temperature During WBH --;5.3 Cardiorespiratory Effects of WBH --;5.4 Biochemical Effects of WBH --;5.5 Hematological Changes --;5.6 Neurological Sequelae --;5.7 Endocrine Function and WBH --;5.8 Gastrointestinal Toxicity --;5.9 Miscellaneous Toxicities --;6 WBH Animal Studies --;6.1 Introduction --;6.2 Large Animals --;6.3 Murine Models --;6.4 Special Considerations --;7 Special Considerations for the Future --;7.1 Nononcological Considerations --;7.2 Implications of WBH Research for General Medical Practice --;7.3 Systemic Hyperthermia: Summary Reflections Regarding Neoplastic Disease --;References.
SUMMARY OR ABSTRACT
Text of Note
All aspects of both preclinical Anticancer effects of elevated (noncauterizing) tem- and clinical WBH, ranging from molecular biology perature were first observed in ancient Egyptian times and physiology to WBH methodologies and clinical (Oleson and Dewhirst 1983).