عنوان

Adeno-Associated Virus (AAV) Vectors in Gene Therapy

(Number (ISBN

3540610766

(Number (ISBN

3642802079

(Number (ISBN

3642802095

(Number (ISBN

9783540610762

(Number (ISBN

9783642802072

(Number (ISBN

9783642802096

Number

b543929

Title Proper

Adeno-Associated Virus (AAV) Vectors in Gene Therapy

General Material Designation

[Book]

First Statement of Responsibility

edited by Kenneth I. Berns, Catherine Giraud.

Place of Publication, Distribution, etc.

Berlin, Heidelberg

Name of Publisher, Distributor, etc.

Springer Berlin Heidelberg

Date of Publication, Distribution, etc.

1996

Specific Material Designation and Extent of Item

(IX, 173 pages 38 illustrations)

Series Title

Current topics in microbiology and immunology, 218.

Text of Note

List of Contents --;Biology of Adeno-associated Virus --;The Roles of AAV Rep Proteins in Gene Expression and Targeted Integration --;Packaging Systems for Adeno-associated Virus Vectors --;The Challenges of Recombinant Adeno-associated Virus Manufacturing: Alternative Use of Adeno-associated Virus Plasmid/Liposome Complexes for Gene Therapy Applications --;Adeno-associated Virus Vectors for Gene Therapy of the Hematopoietic System --;Adeno-associated Virus Vectors for Gene Transfer into Erythroid Cells --;Adeno-associated Virus 2-Mediated Transduction and Erythroid Lineage-Specific Expression in Human Hematopoietic Progenitor Cells --;Development of Adeno-associated Virus Vectors for Gene Therapy of Cystic Fibrosis --;Adeno-associated Virus-Based Vectors As Antivirals.

Text of Note

Viral vectors have been the favored delivery vehicle for gene therapy in recent years. Adeno-associated virus has become a candidate of great interest because of its biological properties which include site specific integration in human chromosome 19. In this volume methods of vector production and use in in vitro and in vivo experi- ments are described, including recent studies with hematopoietic stem cells and non-dividing cells. Various protocols for preparing recombinant AAV vectors and their intracellular delivery are extensively discussed. The first trial of AAV as vector for human gene therapy was conducted in late 1995.

Medical virology.

Medicine.

Microbiology.

Class number

Book number

edited by Kenneth I. Berns, Catherine Giraud.

Catherine Giraud

Kenneth I Berns

Electronic name

[Book]

Y