1 Liquid Water at Low Temperature: Clues for Biology?.- 2 Ab Initio Theoretical Study of Water: Extension to Extreme Conditions.- 3 The Behavior of Proteins Under Extreme Conditions: Physical Concepts and Experimental Approaches.- 4 High-Pressure NMR Spectroscopy of Proteins.- 5 Pressure-Induced Secondary Structure Changes of Proteins Studied by FTIR Spectroscopy.- 6 The Small Angle X-Ray Scattering from Proteins Under Pressure.- 7 Accurate Calculations of Relative Melting Temperatures of Mutant Proteins by Molecular Dynamics/Free Energy Perturbation Methods.- 8 Enzyme Kinetics: Stopped-Flow Under Extreme Conditions.- 9 Pressure Effects on the Intramolecular Electron Transfer Reactions in Hemoproteins.- 10 Marine Microbiology: Deep Sea Adaptations.- 11 Submarine Hydrothermal Vents as Possible Sites of the Origin of Life.- 12 The Effect of Hydrostatic Pressure on the Survival of Microorganisms.- 13 Dynamics of Cell Structure by Pressure Stress in the Fission Yeast Schizosaccharomyces pombe.