Part I. Epidemiology/IGE. Molecular Mechanisms of Isotype Switching to IGE, Donata Vercelli. Cytokines and IGE Regulation, Juha Punnonen and Jan E. de Vries. Environmental Allergens, Thomas A. E. Platts-Mills, Judith A. Woodfolk, and Lisa M. Wheatley. Ontogeny of Allergy, Bengt Bjorksten. Part II. Inflammation: Cellular Aspects. The Role of the Bone Marrow in Allergic Disease, Mark D. Inman, Roma Sehmi, Paul M. O'Byrne, and Judah A. Denburg. The Role of Mast Cells in Inflammation and Homeostasis, Angus J. MacDonald, Fiona L. Wills, Tong-Jun Lin, and A. Dean Befus. Human Langerhans Cells, Thomas Bieber. Eosinophils, Redwan Moqbel and Paige Lacy. Role of Basophils in Allergic Reactions, Peter Valent. Neurogenic Inflammation in Allergic Disease, Peter J. Barnes. Inflammation: Th1/Th2 Cells, Sergio Romagnani. T-Cells in the Pathogenesis of Asthma and Allergic Diseases, Marc Humbert and Stephen R. Durham. Role of CD8+ T-Cells in the Regulation of Immunoglobulin E, Paul A. MacAry and David M. Kemeny. Airway Wall Structure, Peter K. Jeffery, Mariusz J. Gizycki, and Andrew V. Rogers. Epithelium, Mary H. Perdue and Derek M. McKay. Part III. Inflammation: Molecular Aspects. Proinflammatory Cytokines in Allergic Disease, Daniel L. Hamilos. Hemopoietic Cytokines: Function, Receptor, and Signal Transduction, Hirokazu Kurata and Ken-ichi Arai. Adhesion Receptors in Allergic Disease, Andrew J. Wardlaw. Cell/Cytokine Interactions, David H. Broide. Signaling in Mast Cells, Anthony P. Sampson and Martin K. Church. Signaling in Human Basophils, Donald MacGlashan, Jr. Eosinophil Signal Transduction, Hirohita Kita. Part IV. Pathogenesis. Pathogenesis of Allergic Rhinitis, Niels Mygind and Ronald Dahl. Pathogenetic Mechanisms of Urticaria, Allen P. Kaplan. Atopic Eczema, Johannes Ring, Ulf Darsow, and Dietrich Abeck. Pathogenesis of Asthma, Paul M. O'Byrne. Pathogenesis of Allergic Conjunctivitis, Sergio Bonini and Stefano Bonini. Part V. Therapeutics. Glucocorticoids (Corticosteroids),Christopher J. Corrigan. ss-Agonists, Harold S. Nelson. Sodium Cromglycate and Nedocromil Sodium, Alan M. Edwards, Alexis E. Harper, Ken Rainey, and Alan A. Norris. Airway Remodeling and Repair, Peter M. Hockey, Ratko Djukanovic, William R. Roche, and Stephen T. Holgate. Index.