Introduction -- Major classes of contaminants -- Uptake, biotransformation, detoxification, elimination, and accumulation -- Factors influencing bioaccumulation -- Bioaccumulation from food and trophic transfer -- Molecular effects and biomarkers -- Cells, tissues, and organs -- Sublethal effects to individuals -- Acute and chronic lethal effects to individuals -- Effects on populations -- Effects to communities and ecosystems -- Landscape to global effects -- Risk assessment of contaminants -- Conclusions -- Appendixes: 1. International system (SI) of units prefixes -- 2. Miscellaneous conversion factors -- 3. Summary of U.S. laws and regulations -- 4. Summary of European union laws and regulations / Mark Crane and Albania Grosso -- 5. Summary of modern environmental laws and regulations of China / Taiping Wang -- 6. Regulation and management of chemicals in Australia: a 2013 update / Michael StJ. Warne -- 7. Summary of Indian environmental laws and regualtions / S. Bijoy Nandan -- 8. Regulation and management of hazardous chemical substances in South Africa / Theunis Meyer and Claudine Roos -- 9 Derivation of units for simple bioaccumulation models -- 10. Equations for the estimation of exposure