عنوان

Translational research methods for diabetes, obesity and cardiometabolic drug development :

(Number (ISBN

1447149203

(Number (ISBN

9781447149200

Erroneous ISBN

144714919X (print)

Erroneous ISBN

9781447149194

Erroneous ISBN

9781447149194 (print)

Number

dltt

Title Proper

Translational research methods for diabetes, obesity and cardiometabolic drug development :

General Material Designation

[Book]

Other Title Information

a focus on early phase clinical studies /dc Andrew J. Krentz, Lutz Heinemann, Marcu Hompesch, editors

Specific Material Designation and Extent of Item

1 online resource

Text of Note

Includes bibliographical references and index

Text of Note

1. Review of physiology/pathophysiology -- 2. Methods for assessing insulin action in humans -- 3. Assessment of insulin secretion -- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy -- 5. Isotopic tracers for the measurement of metabolic flux -- 6. Measuring food intake in clinical drug development -- 7. Measurement of energy expenditure -- 8. Assessment of body composition -- 9. Assessment of cardiovascular safety of new diabetes drugs

0

Text of Note

This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties

Title

Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development.

International Standard Book Number

9781447149194

Diabetes-- Treatment.

Drug development.

Obesity-- Treatment.

MED-- 071000

Number

Class number

Heinemann, Lutz

Hompesch, Marcus

Krentz, Andrew J.

Ohio Library and Information Network.

Date of Transaction

20150319072409.5

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y