Physiologically-based pharmacokinetic (PBPK) modeling and simulations :
General Material Designation
[Book]
Other Title Information
principles, methods, and applications in the pharmaceutical industry /
First Statement of Responsibility
Sheila Annie Peters
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Hoboken, N.J. :
Name of Publisher, Distributor, etc.
Wiley,
Date of Publication, Distribution, etc.
c2012
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
xvii, 430 p. :
Other Physical Details
ill. ;
Dimensions
24 cm
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references and index
CONTENTS NOTE
Text of Note
Modeling in the pharmaceutical industry -- Physiologically-based modeling -- Review of pharmacokinetic principles -- Physiological model for absorption -- Physiological model for distribution -- Physiological models for drug metabolism and excretion -- Generic whole-body physiologically-based pharmacokinetic modeling -- Variability, uncertainty and sensitivity analysis -- Evaluation of drug-drug interaction risk with PBPK models -- Physiologically-based pharmacokinetics of biotherapeutics -- Data integration and sensitivity analysis -- Hypothesis generation and pharmacokinetic predictions -- Integration of PBPK and pharmacodynamics -- Physiologically-based pharmacokinetic modeling of populations -- PBPK models along the drug discovery and development value chain
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PARALLEL TITLE PROPER
Parallel Title
Physiologically based pharmacokinetic (PBPK) modeling and simulations