عنوان

Translational endocrinology of bone :

(Number (ISBN

012415784X (hbk.)

(Number (ISBN

9780124157842 (hbk.)

Number

dltt

Title Proper

Translational endocrinology of bone :

General Material Designation

[Book]

Other Title Information

reproduction, metabolism, and the central nervous system /

First Statement of Responsibility

edited by Gerard Karsenty

Edition Statement

1st ed

Place of Publication, Distribution, etc.

Waltham, MA :

Name of Publisher, Distributor, etc.

Academic,

Date of Publication, Distribution, etc.

2012

Date

201210

Specific Material Designation and Extent of Item

x, 226 p. :

Other Physical Details

ill. (some col.) ;

Dimensions

28 cm

Text of Note

"Elsevier science & technology books."

Text of Note

Includes bibliographical references and index

Text of Note

Karsenty (genetics and development, Columbia U.) compiles 17 articles by researchers from Europe, the US, Australia, and Japan who discuss the effects of bone on whole-organism physiology and how the study of this discipline aids in the understanding of the pathogenesis of degenerative diseases affecting several organs. Chapters address various hormones and neuromediators ranging from serotonin to osteocalcin, as well as knowledge about the ability of bone to regulate phosphate metabolism. They demonstrate, through examples of hormones emerging during evolution with bone and coordinating the regulation of bone mass accrual, energy metabolism, and reproduction, that the appearance of bone during evolution has impacted the physiology of the entire organism, and also show, through the example of the skeleton, how a genetic-based approach to the study of the physiology of a given organ can reveal multiple new functions, connections with other organs, and novel identities for well-known molecules. They discuss the basic principles of bone cell biology, the central control of bone mass, neuropeptide Y and bone formation, the gastrointestinal tract and the control of bone mass, the skeletal actions of insulin, transcriptional regulation of the endocrine function of bone, regulation of bone resorption, the clinical aspects of fibroblast growth factor 23, bone marrow fat and bone mass, and the significance of organ crosstalk in insulin resistance and type 2 diabetes. Academic Press is an imprint of Elsevier. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com)

Bones-- Growth

Bones-- Metabolism-- Endocrine aspects

Bone and Bones

Number

Edition

Karsenty, Gerard

Date of Transaction

20130107084209.0

Electronic name

[Book]

Y