عنوان

Basic aspects of catechol-O-methyltransferase and the clinical applications of its inhibitors /

(Number (ISBN

0123813263

(Number (ISBN

9780123813268

Number

dltt

Title Proper

Basic aspects of catechol-O-methyltransferase and the clinical applications of its inhibitors /

General Material Designation

[Book]

First Statement of Responsibility

editor, Erkki Nissinen

Date

201012

Specific Material Designation and Extent of Item

xii, 323 pages :

Other Physical Details

illustrations ;

Dimensions

24 cm

Series Title

International review of neurobiology ;

Volume Designation

v. 95

Text of Note

Includes bibliographical references and index

Text of Note

Cover; International Review of Neurobiology; Copyright; Contributors; Preface; Introductory Remarks: Catechol-O-Methyltransferase Inhibition -- An Innovative Approach To Enhance l-Dopa Therapy In Parkinson'S D; The Catechol-O-Methyltransferase Gene: Its Regulation and Polymorphisms; Distribution and Functions of Catechol-O-Methyltransferase Proteins: Do Recent Findings Change The Picture?; Catechol-O-Methyltransferase Enzyme: Cofactor S-Adenosyl-l-Methionine And Related Mechanisms; Biochemistry And Pharmacology Of Catechol-O-Methyltransferase Inhibitors

0

Text of Note

"Since its discovery in 1958, the Catechol-O-methyltransferase (COMT) enzyme has generated a lot of excitement, particularly so in more recent years with the discovery of clinically relevant COMT inhibitors in the late 1980's. While the volume of published research on the COMT enzyme and its inhibitors is substantial, there is no comprehensive, up-to-date source containing all the information available on basic COMT biochemistry and pharmacology, as well as critical review of results from clinical trials. This volume of International Review of Neurobiology summarizes what is currently known about COMT enzyme: its genomics, structure, function and biochemical properties; and presents up-to-date evaluation of the clinical use of COMT inhibitors as an adjunct to levodopa/dopa decarboxylase inhibitor treatment in Parkinson's disease."--Publisher's description

Catecholamines

Parkinson's disease-- Chemotherapy

Psychotropic drugs

Nissinen, Erkki

Date of Transaction

20101221092631.0

Cataloguing Rules (Descriptive Conventions))

rda

Electronic name

[Book]

Y