DNA structure and stability : mutations versus repair -- Regulation of gene expression -- Growth factor signaling and oncogenes -- The cell cycle -- Growth inhibition and tumor suppressor genes -- Apoptosis -- Stem cells and differentiation -- Metastasis -- The immune system, infections, and inflammation -- Nutrients, hormones, and gene interactions -- The cancer industry : drug development, pharmacogenomics, and clinical trial design -- Cancer in the future : focus on cancer vaccines and technology -- Appendix 1: Cell cycle regulation -- Appendix 2: Centers for cancer research -- Glossary
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SUMMARY OR ABSTRACT
Text of Note
Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents