biology, technology, and genetics of STR markers /
First Statement of Responsibility
John M. Butler.
EDITION STATEMENT
Edition Statement
2nd ed.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Boston :
Name of Publisher, Distributor, etc.
Elsevier Academic Press,
Date of Publication, Distribution, etc.
c2005.
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
xvii, 660 p. :
Other Physical Details
ill. (some col.) ;
Dimensions
26 cm.
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references and indexes.
CONTENTS NOTE
Text of Note
Overview and history of DNA typing -- DNA biology review -- Sample collection, DNA extraction and DNA quantitation -- The polymerase chain reaction (DNA amplification) -- Commonly used short tandem repeat markers and commercial kits -- Biology of STRs : stutter products, non-template addition, microvariants, null alleles, and mutation rates -- Forensic issues : degraded DNA, PCR inhibition, contamination, mixed samples and low copy number -- Single nucleotide polymorphisms and other bi-allelic markers -- Y chromosome DNA testing -- Mitochondrial DNA analysis -- Non-human DNA testing and microbial forensics -- DNA separation methods : slab-gel and capillary electrophoresis -- DNA detection methods : fluorescent dyes and silver-staining -- Instrumentation for STR typing : ABI 310, ABI 3100, FMBIO systems -- STR genotyping issues -- Laboratory validation -- New technologies, automation, and expert systems -- Combined DNA index system (CODIS) and the use of DNA databases -- Basic genetic principles, statistics, and probability -- STR population database analyses -- Profile frequency estimates, likelihood ratios, and source attribution -- Approaches to statistical analysis of mixtures and degraded DNA -- Kinship and parentage testing -- Mass disaster DNA victim identification.