Randomized controlled trials: the basics -- Types of randomized controlled trials -- Bias in randomized controlled trials -- Assessing the quality of randomized controlled trials: why, what, how, and by whom? -- Reporting and interpreting individual trials: the essentials -- From individual trials to groups of trials: reviews, meta-analyses and guidelines -- From trials to decisions: the basis of evidence-based health care -- Ethics and clinical trials: are they compatible? -- Reprise: more musings.