edited by Massimiliano Gnecchi, Department of Molecular Medicine, Unit of Cardiology, University of Pavia, Pavia, Italy, Department of Cardiothoracic and Vascular Sciences -- Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Laboratory of Experimental Cardiology for Cell and Molecular Therapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, Department of Medicine, University of Cape Town, Cape Town, South Africia.