عنوان

Computational design of ligand binding proteins

(Number (ISBN

1493935674

(Number (ISBN

9781493935673

Erroneous ISBN

1493935690

Erroneous ISBN

9781493935697

Number

dltt

Title Proper

Computational design of ligand binding proteins

General Material Designation

[Book]

First Statement of Responsibility

edited by Barry L. Stoddard, Division of Basic Sciences, Fred Hutchison Cancer Research Center, Seattle, Washington, USA.

Place of Publication, Distribution, etc.

New York :

Name of Publisher, Distributor, etc.

Humana Press,

Date of Publication, Distribution, etc.

[2016]

Series Title

Methods in molecular biology,

Series Title

Springer protocols

Volume Designation

1414

ISSN of Series

1940-6029 ;

Text of Note

Includes bibliographical references and index.

Text of Note

This volume provides a collection of protocols and approaches for the creation of novel ligand binding proteins, compiled and described by many of today's leaders in the field of protein engineering. Chapters focus on modeling protein ligand binding sites, accurate modeling of protein-ligand conformational sampling, scoring of individual docked solutions, structure-based design program such as ROSETTA, protein engineering, and additional methodological approaches. Examples of applications include the design of metal-binding proteins and light-induced ligand binding proteins, the creation of binding proteins that also display catalytic activity, and the binding of larger peptide, protein, DNA and RNA ligands. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.--

Carrier proteins.

Ligands.

Protein binding.

Proteomics-- Methodology.

Carrier Proteins.

Computational Biology-- methods.

Computer Simulation-- utilization.

Ligands.

Protein Engineering.

Stoddard, Barry L.

Date of Transaction

20181223152944.0

Electronic name

[Book]

Y