عنوان

Gigaseal formation in patch clamping :

(Number (ISBN

3642391281 (electronic bk.)

(Number (ISBN

9783642391286 (electronic bk.)

Erroneous ISBN

9783642391279

Number

b435071

Title Proper

Gigaseal formation in patch clamping :

General Material Designation

[Book]

Other Title Information

with applications of nanotechnology /

First Statement of Responsibility

Majid Malboubi, Kyle Jiang

Specific Material Designation and Extent of Item

1 online resource

Series Title

Springer briefs in applied sciences and technology

Text of Note

Electronic resource

Text of Note

Includes bibliographical references

Text of Note

This book presents an investigation of gigaseal formation using micro/nanotechnology. The aims of the book are twofold. First, it explains the mechanisms of gigaseal formation using the latest discoveries. Second, it provides practical techniques for frequent formation of high resistance seals. The formation of a high-resistance electrical seal, also known as a gigaseal, between a cell membrane and a glass micropipette tip is essential in patch-clamp experiments. Even though four decades have passed since the introduction of the patch-clamping technique by Neher and Sakmann, gigaseal formation remains an obstacle in developing the high-throughput ion channel screening systems required by the pharmaceutical industry. Here the authors share their latest methods for achieving gigaseal formation and describe techniques that are highly desirable at both research and industrial levels. Nanotechnology has been found to be a powerful tool for studying and modifying glass micropipettes and in tackling the problem of gigaseal formation

Nanotechnology

Patch-clamp techniques (Electrophysiology)

SCI-- 007000

Number

Edition

Class number

Malboubi, Majid

Jiang, Kyle

Ohio Library and Information Network

Date of Transaction

20150609113959.0

Electronic name

[Book]

Y