عنوان

Apoptosis, senescence, and cancer

(Number (ISBN

1588295273 (alk. paper)

(Number (ISBN

9781588295279 (alk. paper)

Number

b431762

Title Proper

Apoptosis, senescence, and cancer

General Material Designation

[Book]

First Statement of Responsibility

edited by David A. Gewirtz, Shawn E. Holt, Steven Grant.

Edition Statement

2nd ed.

Place of Publication, Distribution, etc.

Totowa, N.J. :

Name of Publisher, Distributor, etc.

Humana Press,

Date of Publication, Distribution, etc.

c2007.

Specific Material Designation and Extent of Item

xvii, 599 p. :

Other Physical Details

ill. ;

Dimensions

26 cm.

Series Title

Cancer drug discovery and development

Text of Note

Includes bibliographical references and index.

Text of Note

The intrinsic pathway of apoptosis -- The extrinsic pathway of apoptosis -- Evaluating the importance of apoptosis and other determinants of cell death and survival -- Mitotic catastrophe -- Autophagy and autophagic cell death -- Regulation and function of detachment-induced cell death (anoikis) in cancer progression and metastasis -- Structure and function of the telomere -- Overview of senescence -- Contributions of telomerase to tumorigenesis -- The role of telomeres in genomic instability -- Overview of the DNA damage checkpoint: ATM and ATR -- Interactions between myc- and cyclin-dependent kinase inhibitors in cancer -- Interplay between [gamma]H2AX and 53BP1 pathways in DNA double-strand break repair response -- DNA-dependent protein kinase in repair, apoptosis, telomere maintenance, and chemotherapy -- Resistance/signaling pathways -- Ceramide and multidrug resistance -- Chemo- and radiosensitization through inhibition of PI3K/Akt signaling -- The advancement of epidermal growth factor receptor inhibitors in cancer therapy -- Antimetabolites -- Topoisomerase I poisons and apoptotic topoisomerase I-DNA complexes -- Perturbations of cellular functions by topoisomerase II inhibitors: all roads lead to cell death? -- The significance of poly-targeting in apoptosis induction by alkylating agents and platinum drugs -- Contributions of apoptosis and senescence to cytotoxicity produced by microtubule-stabilizing agents -- Tyrosine kinase inhibitors -- Monoclonal antibodies in lymphomas -- Role of apoptosis in anti-angiogenic cancer therapies -- Photodynamic therapy-induced apoptosis -- Modulation of TRAIL signaling for cancer therapy.

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Text of Note

Mode of access: World Wide Web.

Title

Apoptosis, senescence, and cancer

Title

OhioLINK electronic book center

Title

SpringerLink

Apoptosis.

Cancer cells-- Growth-- Regulation.

Cancer-- Chemotherapy.

Cancer-- Radiotherapy.

Gewirtz, David A.

Grant, Steven.

Holt, Shawn E.

Date of Transaction

20080509101730.0

Electronic name

[Book]

Y