عنوان

Molecular defects in cardiovascular disease /

(Number (ISBN

1441971297

(Number (ISBN

1441971300

(Number (ISBN

9781441971296

(Number (ISBN

9781441971302

Number

b430525

Title Proper

Molecular defects in cardiovascular disease /

General Material Designation

[Book]

First Statement of Responsibility

Naranjan S. Dhalla, Makoto Nagano, Bohuslav Ostadal, editors

Specific Material Designation and Extent of Item

1 online resource (xviii, 382 pages) :

Other Physical Details

illustrations (some color)

Text of Note

Includes bibliographical references and index

Text of Note

Calcium Overloading-Induced Oxidative Stress-Mediated Cellular and Subcellular Remodeling -- Intracellular MMP-2: Role in Normal and Diseased Hearts -- Control of the Mesenchymal-Derived Cell Phenotype by Ski and Meox2: A Putative Mechanism for Postdevelopmental Phenoconversion -- Elevated Na+-H+ Exchanger Expression and Its Role in Myocardial Dise -- Impact of Perinatal Chronic Hypoxia on Cardiac Tolerance to Acute Ischemia -- Stem Cell, MicroRNA and Redox Cycling -- Cardiac Cell Therapy: Present and Future -- Macroscopic and Microscopic Aspects of Cardiac Dysfunction in Congestive Heart Failure -- Cardiac Dysfunction and Metabolism: Unravelling the Molecular Cross-Talk -- Metabolic Remodelling of the Hypertrophied Heart -- Mechanisms for the Regulation of Phospholipase C Gene Expression in Cardiac Hypertrophy -- Molecular Changes in Fatty Acid Oxidation in the Failing Heart -- Cardiolipin Metabolism in Experimental and Human Heart Failure -- Mechanisms Underlying Development of Cardiomyocyte Hypertrophy via Na-H Exchange Stimulation -- The Structural Basis of Cardiac Dysfunction in Human Heart Failure -- Hormonal Mechanisms of Cardiac Remodeling in Heart Failure -- Modulators of Remodeling After Myocardial Infarction -- Phosphodiesterase-5 Inhibitors in Protection Against Doxorubicin-Induced Cardiomyopathy -- Molecular Basis of Pulmonary Hypertension in Left Heart Failure -- Modulation of Gi Protein Expression in Hypertension: Molecular Mechanisms -- Vascular Dysfunction in Heart Disease -- Cellular and Molecular Mechanisms Associated with Salicylate Inhibition of Intimal Hyperplasia Following Balloon Catheter-Induced Vascular Injury -- Involvement of Growth Factor Receptor and Nonreceptor Protein Tyrosine Kinases in Endothelin-1 and Angiotensin II-Induced Signaling Pathways in the Cardiovascular System -- Sarco/Endoplasmic Reticulum Ca2+ Pump Damage by Oxidative Stress: Implications for Ca2+ Entry -- Obesity-Hypertension: Leptin as the Common Link to Cardiovascular and Renal Dysregulation -- Cardiorenal Protection in Diabetes Mellitus -- Molecular Mechanisms in the Pathogenesis of Diabetic Cardiomyopathy

0

Text of Note

Molecular Defects in Cardiovascular Disease¡provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics.¡ Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment.¡ The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction.¡ The remaining two sections provide a more clinical focus.¡ The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling. ¡It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure.¡ The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end.¡ ¡ A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology.¡ It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies

Source for Acquisition/Subscription Address

Springer

Stock Number

978-1-4419-7129-6

Title

Molecular defects in cardiovascular disease.

Cardiovascular system-- Diseases-- Molecular aspects

Cardiovascular Diseases-- pathology.

Molecular Biology.

Medical Biochemistry

Medicine & Public Health

MED010000

MJD

Number

Edition

Class number

Book number

Class number

Dhalla, Naranjan S

Nagano, Makoto,1928-

Ošt̕ádal, Bohuslav

Date of Transaction

20170726082053.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y