Reviews of Physiology, Biochemistry and Pharmacology
General Material Designation
[Book]
First Statement of Responsibility
edited by S. G. Amara, E. Bamberg, M. P. Blaustein, H. Grunicke, R. Jahn, W. J. Lederer, A. Miyajima, H. Murer, N. Pfanner, G. Schultz, M. Schweiger.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Berlin, Heidelberg :
Name of Publisher, Distributor, etc.
Springer Berlin Heidelberg,
Date of Publication, Distribution, etc.
2002.
SERIES
Series Title
Reviews of Physiology, Biochemistry and Pharmacology,
Volume Designation
144
ISSN of Series
0303-4240 ;
CONTENTS NOTE
Text of Note
Phospholipase D -- structure, regulation and function -- Endotoxin tolerance -- mechanisms and beneficial effects in bacterial infection -- The structural basis of G-protein-coupled receptor function and dysfunction in human disease.
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SUMMARY OR ABSTRACT
Text of Note
In this volume of Reviews there are three outstanding articles, one on phspholipase D, an enzyme that is widely distributed in bacteria, protozoa, fungi, plants and animals. Phospholipase D carries out a transphosphatidylation reaction, which is unique to this enzyme. This review is focussed on mammalian PLDs. The second review deals with endotoxin tolerance, the term which describes the phenomenon that immune responses and metabolic changes are mitigated after repeated LPS administration. The third article summarizes the current knowledge relevant to understanding the molecular basis of GPCR function and focusses on the underlying mechanisms of GPCR malfunctions responsible for diferent human diseases.