Estrogen action, selective estrogen receptor modulators, and women's health
General Material Designation
[Book]
Other Title Information
progress and promise /
First Statement of Responsibility
editor, V Craig Jordan.
.PUBLICATION, DISTRIBUTION, ETC
Place of Publication, Distribution, etc.
Singapore :
Name of Publisher, Distributor, etc.
Distributed by World Scientific Pub. Co.,
Date of Publication, Distribution, etc.
c2013.
PHYSICAL DESCRIPTION
Specific Material Designation and Extent of Item
xxxvi, 507 p. :
Other Physical Details
ill. (some col.)
INTERNAL BIBLIOGRAPHIES/INDEXES NOTE
Text of Note
Includes bibliographical references and index.
REPRODUCTION NOTE
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Available to subscribing institutions.
CONTENTS NOTE
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ch. 1. A century of deciphering the control mechanisms of estrogen action in breast cancer: the origins of targeted therapy and chemoprevention / V. Craig Jordan -- ch. 2. Diethylstilbestrol: a tragedy in reproductive endocrinology but a pioneering cancer treatment / Joan Lewis-Wambi and V. Craig Jordan -- ch. 3. Oral contraceptives and women's health / V. Daniel Castracane and V. Craig Jordan -- ch. 4. Hormone replacement therapy and women's health / Jennifer Eng-Wong, Ifeyinwa Obiorah and V. Craig Jordan -- ch. 5. Induction of ovulation by nonsteroidal antiestrogens / Ifeyinwa Obiorah and V. Craig Jordan -- ch. 6. Clues about estrogen and antiestrogen action from X-ray crystallography / Geoffrey L. Greene and V. Craig Jordan -- ch. 7. Coregulators and their role in selective estrogen receptor modulator action / Christopher D. Chien, Anton Wellstein and Anna Riegel -- ch. 8. Role of estrogen in familial breast cancer / Eliot Rosen and Claudine Isaacs -- ch. 9. Advances with aromatase inhibitors / Saranya Chumsri ... [et al.] -- ch. 10. Adjuvant antihormone therapy / Anthony Howell and V. Craig Jordan -- ch. 11. Pharmacogenomics of tamoxifen / Hiltrud B. Brauch and V. Craig Jordan -- ch. 12. Antihormone drug resistance / Robert Clarke and V. Craig Jordan -- ch. 13. Novel selective estrogen receptor modulators / Surojeet Sengupta and V. Craig Jordan -- ch. 14. Endocrine prevention of breast cancer / Trevor J. Powles, Russell E. McDaniel and V. Craig Jordan -- ch. 15. Selective androgen receptor modulators as improved androgen therapy for women / Christopher C. Coss and James T. Dalton -- ch. 16. An emerging principle: selective nuclear receptor modulators / Ping Fan and V. Craig Jordan.
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SUMMARY OR ABSTRACT
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This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs - tamoxifen and raloxifene - are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.