edited by Xin-Hua Feng, Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang Province, China ; Departments of Surgery,and Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas, USA, Pinglong Xu, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang Proviince, China, Xia Lin, Department of Surgery, Baylor College of Medicine, Houston, USA.