Chapter 1 Scientific and Commercial Value of Drug Repurposing / David Cavalla -- chapter 2 Repurposing for Alzheimer's and Parkinson's Diseases -- The Ideas, the Pipeline, the Successes, and the Disappointments / Hermann Mucke -- chapter 3 Contribution of Not-for-Profit Organizations to Drug Repurposing / Bruce Bloom -- section I The Rationale and Economics of Drug Repositioning -- chapter 4 Systematic Drug Repositioning / Spyros N. Deftereos Aris Persidis Andreas Persidis Eftychia Lekka Christos Andronis Vassilis Virvillis -- chapter 5 Technical Tools for Computational Drug Repositioning / Francesco Napolitano -- chapter 6 RNAi Screening toward Therapeutic Drug Repurposing / Nichole Orr-Burks Byoung-Shik Shim Olivia Perwitasari Ralph A. Tripp -- chapter 7 Phenotypic Screening / Christine M. Macolino-Kane John R. Ciallella Christopher A. Lipinski Andrew G. Reaume -- section II Repositioning Approaches and Technologies From Serendipity to Systematic and Rational Strategies -- chapter 8 A Case Study -- Chlorpromazine / Francisco López-Muñoz Cecilio Álamo Silvia E. García-Ramos -- chapter 9 Drug Repurposing for Central Nervous System Disorders -- A Pillar of New Drug Discovery / Mondher Toumi Aleksandra Caban Anna Kapuśniak Szymon Jarosławski Cecile Rémuzat -- chapter 10 Repurposing Opportunities for Parkinson's Disease Therapies / Giulia Ambrosi Silvia Cerri Fabio Blandini -- chapter 11 Drug Candidates for Repositioning in Alzheimer's Disease / Maria P. del Castillo-Frias Andrew J. Doig -- chapter 12 Promising Candidates for Drug Repurposing in Huntington's Disease / Francesca Romana Fusco Emanuela Paldino -- chapter 13 Drug Repositioning Opportunities in Psychiatry / Alexander W. Charney Joseph R. Scarpa Douglas M. Ruderfer Dennis S. Charney -- chapter 14 Pharmacology of Amyotrophic Lateral Sclerosis -- Old Strategies and New Perspectives / Tiziana Petrozziello Valentina Tedeschi Alba Esposito Agnese Secondo -- chapter 15 Repositioning Clinic-Ready Compounds for the Treatment of Spinal Muscular Atrophy / Faraz Farooq -- chapter 16 Rescuing Ischemic Brain Injury by Targeting the Immune Response through Repositioned Drugs / Diana Amantea Giacinto Bagetta -- section III Drug Repositioning for Nervous System Diseases.