عنوان

DIAGNOSTIC ACCURACY FOR ALTERNATIVE CERVICAL CANCER SCREENING STRATEGIES-SYSTEMATIC REVIEW AND META-ANALYSIS,ارزش تشخیصی و تعیین استراتژی های غربالگری سرطان سرویکس- متاآنالیز و سیستماتیک ریویو

Number

92058P

.Language of Text, Soundtrack etc

انگلیسی

Title Proper

DIAGNOSTIC ACCURACY FOR ALTERNATIVE CERVICAL CANCER SCREENING STRATEGIES-SYSTEMATIC REVIEW AND META-ANALYSIS

Title Proper

ارزش تشخیصی و تعیین استراتژی های غربالگری سرطان سرویکس- متاآنالیز و سیستماتیک ریویو

General Material Designation

[Dissertation]

First Statement of Responsibility

Narmin Karisani

First Statement of Responsibility

نرمین کریسانی

Name of Publisher, Distributor, etc.

Tehran University of Medical Sciences, Medicine school

Date of Publication, Distribution, etc.

2016

Specific Material Designation and Extent of Item

128p

Dissertation or thesis details and type of degree

دکتری تخصصی

Dissertation or thesis details and type of degree

Speciality

Discipline of degree

زنان و زایمان

Discipline of degree

Obstetrics and Gynacology

Text of Note

Background: Cervical cancer is great menace worldwide comprising a major concern of public health. It is fourth most common cancer in women. More than 85 percent of these deaths occur in low- and medium- resource countries, where programs to detect precancerous lesions are not available or are beyond the means of most women and it is predicted to climbs to 91.5% by 2030, SO Well-organized quality-controlled screening is the best approach to reduce the burden of cervical cancer.Objective: to assess and to provide an updated summary estimation of the diagnostic accuracy of seven cervical cancer screening as alternative standalone methodes, including: Conventional pap smear, Liquid based cytology, High risk HPV DNA testing by clinician sampling and self-sampling, Cervicography, Visual inspection with acetic acid (VIA), Visual inspection with Lugol’s iodine (VILI).Search method: We performed a systematic search to identify articles in the evaluation of diagnostic accuracy of screening tests, and using histopathology as the reference standard. To this end, we searched the following databases: MEDLINE (via pubmed), EMBASE, Web of Science, Scopus, Cochrane library up to March 2016 according to the search strategies stated in the protocol Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy. Selection criteria: We included studies that met the following main inclusion criteria: asymptomatic women, history of sexual activity, no screening previously, alternative methods of screening tests as standalone testes or comparing for primary screening, no past history of cervical neoplasm, intact cervix. We excluded reports with: high risk population, women who had a history of CIN, pregnant women, menstruating period. Data collection and analysis: For all eligible report, two review authors extracted relevant information and diagnostic data. We assessed data quality using a standard procedure according to the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) criteria. We performed diagnostic accuracy meta-analysis using the hierarchical bivariate method.Main result: We identified 69 cross sectional studies that were eligible according to the inclusion criteria (VIA: 152824 women, VILI: 88102 women, LBS: 8568 women, CPS: 91728 women, CHPV testing: 68450 women, SHPV testing: 68450 women, cervicography: 6575 women).The combined estimates of sensitivity of VIA, VILI, CPS, LBS, CHPV, SHPV, cervicography were 64%, 80%, 55%, 70%, 70% and 67% respectively; the combine values of specificity of these screening strategies were 88%, 88%, 96%, 59%, 94%, and 95% respectively; the diagnostic odds ratio were 13.4, 31.7, 35, 3.4, 37, 39 respectively.Authors' conclusion: VILI was associated with the best balance of sensitivity and specificity, shows surprising promise in detecting cervical cancer and precancerous. Our findings draw attention to an attractive opinion to facilitate the collection of specimens for DNA HPV by patient in settings where they don’t have access to regular screening program. Self-sampling may be a suitable alternative method for studies on HPV transmission and vaccine trials and also cervicography might be a good choice to identify cancerous and precancerous lesions. Further studies are required to evaluating diagnostic accuracy of cervicography.

Cervical cancer

سرطان دهانه رحم

screening

غربالگری

Diagnostic value

ارزش تشخیصی

Relator Code

, Author

Relator Code

, Author

Karisani, Narmin

کریسانی، نرمین

Relator Code

, Thesis advisor

Relator Code

, Thesis advisor

Relator Code

, Thesis advisor

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, Thesis advisor

Relator Code

, Consulting advisor

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, Consulting advisor

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, Consulting advisor

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, Consulting advisor

Kashanian, Maryam

کاشانیان، مریم

Badakhsh, Mohammad Hossein

بدخش، محمدحسین

Baradaran, Hamid Reza

برادران، حمیدرضا

Amini Moghadam, Soheila

امینی مقدم، سهیلا

Entry Element

Tehran University of Medical Sciences, Medicine school

Country

ایران

Date of Transaction

20230529

Call Number

11087T

Electronic name

p

TL

276903

a

Y