Cold-Adapted Yeasts: a Lesson from the Cold and a Challenge for the XXI Century -- Methods for the Isolation and Investigation of the Diversity of Cold-Adapted Yeasts and their ex situ Preservation in Worldwide Collections -- Cold-Adapted Yeasts in Arctic Habitats -- Cold-Adapted Yeasts in Antarctic Deserts -- Cold-adapted yeasts in Alpine and Apennine glaciers -- Cold-Adapted Yeasts in Patagonian Habitats -- Cold-Adapted Yeasts in Deep-Sea Environments -- Black Yeasts in Cold Habitats -- Production of Pigments and Photo-Protective Compounds by Cold-Adapted Yeasts -- Changes in Lipids Composition and Fluidity of Yeast Plasma Membrane as Response to Cold -- Cold-Shock Response and Adaptation to Near-Freezing Temperature in Cold-Adapted Yeasts -- Production of Antifreeze Proteins by Cold-Adapted Yeasts -- Role of Sterol Metabolism and Endoplasmic-Reticulum-Associated Degradation )ERAD( of Proteins in Cold Adaptation of Yeasts -- Subzero Activity of Cold-Adapted Yeasts -- Fundamentals of Cold-Active Enzymes -- Cold-Active Yeast Lipases: Recent Issues and Future Prospects -- Miscellaneous Cold-Active Yeast Enzymes of Industrial Importance -- Production of Polymers and other Compounds of Industrial Importance by Cold-Adapted Yeasts -- Low-Temperature Production of Wine, Beer and Distillates using Cold-Adapted Yeasts -- Cold-Adapted Yeasts as Biocontrol Agents: Biodiversity, Adaptation Strategies and Biocontrol Potential -- Bioremediation and Biodegradation of Hydrocarbons by Cold-Adapted Yeasts -- Heterologous Expression of Proteins from Cold-Adapted Yeasts in Suitable Hosts: Methods and Applications -- Food Spoilage by Cold-adapted Yeasts