عنوان

The Development and Characterization of Computationally Optimized Broadly Reactive Antigen (Cobra) for H5NX Influenza Viruses

شماره

TL53378

زبان متن نوشتاري يا گفتاري و مانند آن

انگلیسی

عنوان اصلي

The Development and Characterization of Computationally Optimized Broadly Reactive Antigen (Cobra) for H5NX Influenza Viruses

نام عام مواد

[Thesis]

نام نخستين پديدآور

Nunez, Ivette Ariela

نام ساير پديدآوران

Ross, Ted M.

نام ناشر، پخش کننده و غيره

University of Georgia

تاریخ نشرو بخش و غیره

2020

متن يادداشت

193 p.

جزئيات پايان نامه و نوع درجه آن

Ph.D.

کسي که مدرک را اعطا کرده

University of Georgia

امتياز متن

2020

متن يادداشت

Avian influenza viruses pose a constant threat to the human population and continuously circulate around the globe in wild water fowl species. Due to migratory patterns, these hosts commonly come into contact with susceptible species including domestic chicken, turkeys and ducks. Close contact with such species leaves poultry farmers and live-market patrons at risk for contracting this deadly disease. Current strategies to contains such spill-over events can become problematic, especially those concerning culling and have negative economic impacts. Multiple countries, including the United States, depend on the poultry industry as a main source of economical income. When avian influenza viruses spill over into the human population, the results are catastrophic, ultimately resulting in systemic infection and ultimately death. Vaccines currently stockpiled for such an outbreak are poorly immunogenic and are obsolete facing the rapidly changing antigenic nature of influenza viruses. Combating this problematic virus is centered around developing an avian influenza vaccine that is able to induce cross-reactive antibodies against multiple viral clades, is highly immunogenic, and involves a dose-sparing technique. The studies discussed in this body of work investigate the molecular epitopes responsible for antibody elicitation, design of new immunogenic vaccines, and explores the importance of pre-immune status on avian influenza virus infection. The importance of glycosylation of hemagglutinin based vaccines was explored through site-directed mutagenesis, and was thoroughly tested in a mouse pre-clinical model of disease. We demonstrated that glycosylation of the hemagglutinin determines immunogenicity and effectiveness of eliciting cross-reactive antibodies against multiple viral clades.

اصطلاح موضوعی

Immunology

اصطلاح موضوعی

Public health

اصطلاح موضوعی

Virology

مستند نام اشخاص تاييد نشده

Nunez, Ivette Ariela

مستند نام اشخاص تاييد نشده

Ross, Ted M.

مستند نام تنالگان تاييد نشده

University of Georgia

نام الکترونيکي

فرمت انتشار

p

نوع ماده

[Thesis]

کد کاربرگه

276903

سطح دسترسي

a

تكميل شده

Y