عنوان

The flaviviruse

(electronic bk.)

0080493823

IR

ebook817

انگلیسی

IR

The flaviviruse

[Electronic Resource]

:pathogenesis and immunity

/ edited by Thomas J. Chambers, Thomas P. Monath

Amsterdam ;London

: Elsevier,

, c2003.

1 online resource (xiv, 486 p., [18] p. of plates)

: ill. (some col.)

(Advances in virus research

; v. 60)

e

Includes bibliographical references and index.

of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. * Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions. * New, detailed information on the pathogenesis and immunology of the Flavivirus family. * Descibes the technologies that have contributed to our current knowledge about the Flaviviruses. * Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease. * An exhaustive compendium of current and past knowledge on the Flavivirus family.

Over 50

Cover -- Contents -- Chapter 1. Molecular Determinants of Virulence: The Structural and Functional Basis for Flavivirus Attenuation -- I. Introduction. -- II. Morphology and Genome Structure. -- III. Molecular Determinants of Virulence -- IV. Conclusion -- References -- Chapter 2. Genetic Resistance to Flaviviruses -- I. Introduction -- II. Initial Discoveries of Genetic Resistance to Flaviviruses in Mice -- III. Flavivirus Genetic Resistance in Wild Mice -- IV. Development of Congenic Flavivirus-Resistant and -Susceptible Mouse Strains -- V. Virus Specificity of the Flvr Phenotype in Mice -- VI. Characteristics of the Flvr Phenotype -- VII. Other Characteristics of Resistant C3H. PRI-Flvr Mice -- VIII. Mapping the Flv Gene to Chromosome 5 -- IX. Analysis of Other Known Genes that Map Close to the Flv Locus on Chromosome 5 -- X. Positional Cloning of the Flv Gene -- XI. Identification of the Flv Gene as Oas1b -- XII. Possible Mechanism of Action of the Resistant Allele of the Oas1b Gene -- XIII. Conclusions -- References -- Chapter 3. Immunobiology of Mosquito-Borne Encephalitic Flaviviruses -- I. Introduction -- II. Innate Immune Responses -- III. Adaptive Immune Response -- IV. Virus-Host Interplay in Immunity and Pathogenesis -- References -- Chapter 4. Immune Modulation by Flaviviruses -- I. Introduction -- II. Strategies for Virus Survival in the Immune-Competent Host -- III. Flavivirus Upregulates Cell Surface Recognition Molecules -- IV. Mechanisms of Upregulation -- V. Models of WNV Disease Pathogenesis -- VI. The Paradox of Cell Surface Moldecule Upregulation, Immunopathology, and Virus Survival -- VII. Flavivirus Modulation of Adaptive Immune Responses: A Hypothesis -- VIII. Maternal Tolerance: A Model of Embryonic Implantation -- IX. Conclusions -- References -- Chapter 5. Mechanisms of DengueVirus-Induced Cell Death -- I. Introduction -- II. Apoptosis and Necrosis -- III. Molecular Machinery of Apoptosis -- IV. Virus-Induced Apoptosis -- V. Apoptotic Cell Death in Response to Dengue Virus Infection -- VI. Concluding Remarks -- References -- Chapter 6. Dynamics Flavivirus Infection in Mosquitoes -- I. Mosquito Vectors Associated with Flaviviruses -- II. Flavivirus Infection of and Replication in the Mosquito Vector -- III. Vectorial Capacity -- IV. Impact of Reproductive Biology on Dynamics of Flavivirus Transmission -- V. Role of the Vector in Perpetuation of Virus over Adverse Seasons and Years -- VI. Genetics of Infection -- VII. Vector Control -- VIII. Future Directions -- References. -- Chapter 7. Dynamics of Infection in Tick Vectors and at the Tick-Host Interface -- I. Introduction to Ticks -- II. Tick-Borne Flaviviruses -- III. Anatomy and Dynamics of Infection in Ticks -- IV. Nonviremic Transmission -- V. Population Biology of Tick-Borne Flaviviruses -- VI. Tick-Borne Transmission on Immune Hosts -- VII. Role of Skin in Tick-Borne Transmission -- VIII. Saliva-Activated Transmission -- IX. Host Modulation by Tick Saliva -- X. The ''Red Herring'' Hypothes.

Advances in virus research

v. 60

Flaviviruses.

Chambers, Thomas J

Monath, Thomas P

ایران

QR,395,.F53,2003eb

0120398605.pdf

0

old catalog

e

BL

1

a

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