1. Management of Information in Distributed Biomedical Collaboratories / David B. Keator -- 2. Enabling Public Data Sharing: Encouraging Scientific Discovery and Education / Christine Fennema-Notestine -- 3. Mediator Infrastructure for Information Integration and Semantic Data Integration Environment for Biomedical Research / Jeffrey S. Grethe, Edward Ross, David Little, Brian Sanders, Amarnath Gupta, and Vadim Astakhov -- 4. System Biology of Gene Regulation / Michael Baitaluk -- 5. Current Computational Methods for Prioritizing Candidate Regulatory Polymorphisms / Stephen Montgomery -- 6. Methods of Information Geometry in Computational System Biology )Consistency between Chemical and Biological Evolution( / Vadim Astakhov -- 7. Protein Structure Prediction Based on Sequence Similarity / Lukasz Jaroszewsky -- 8. Applications of Bioinformatics to Protein Structures: How Protein Structure and Bioinformatics Overlap / Gye Won Han, Chris Rife, and Michael R. Sawaya -- 9. Knowledge Discovery via Machine Learning for Neurodegenerative Disease Researchers / I. Burak Ozyurt and Gregory G. Brown -- 10. Brain Model of Text Animation as a Data Mining Strategy / Tamara Astakhova and Vadim Astakhov -- 11. Processes Parallel Execution Using Grid Wizard Enterprise / Marco Ruiz -- 12. Single Sign-On in a Grid Portal / Ramil V. Manansala