عنوان

Quantitative modeling in toxicology

English

Quantitative modeling in toxicology

Chichester

John Wiley & Sons

c2010

xvii, 485 p.: ill

Includes bibliographical references and index

editors, Kannan Krishnan, Melvin E. Andersen

1

Machine generated contents note: Preface -- About the Editors -- About the Book -- List of Contributors -- Section1: Introduction -- Chapter 1 Quantitative modeling in toxicology: An introduction -- Melvin E. Andersen and Kannan Krishnan -- Section2: Physiologically-based toxicokinetic and pharmacokinetic )PBPK( modeling -- Chapter 2 PBPK modeling: a primer -- Kannan Krishnan, George Loizou, Martin Spendiff, John Lipscomb and Melvin E. Andersen -- Chapter 3 Pharmacokinetic modeling with Manganese - An essential element -- Andy Nong, Michael Taylor, Miyoung Yoon, and Melvin E. Andersen -- Chapter 4 Physiologically-based modeling of pharmacokinetic interactions in chemical mixtures -- Sami Haddad, Robert Tardif, Jonathan Boyd, and Kannan Krishnan -- Chapter 5 Physiological Parameters and Databases for PBPK Modeling -- Douglas O. Johns, Elizabeth Oesterling Owens, Chad M. Thompson, Babasaheb Sonawane, Dale Hattis and Kannan Krishnan -- Section3: Modeling toxicant-target interactions -- Chapter 6 Modeling cholinesterase Inhibition -- Charles Timchalk, Paul M. Hinderliter,and Torka S. Poet -- Chapter 7 Modeling of Protein Induction and dose-dependent hepatic sequestration -- Andy Nong and Melvin E. Andersen -- Chapter 8 Bistable Signaling Motifs and Cell Fate Decisions -- Sudin Bhattacharya, Qiang Zhang, and Melvin E. Andersen M.E. -- Chapter 9 Ultrasensitive Response Motifs in Biochemical Networks -- Qiang Zhang, Sudin Bhattacharya, Courtney G. Woods, and Melvin E. Andersen -- Chapter 01 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks -- Melvin E. Andersen, Qiang Zhang, and Sudin Bhattacharya --Machine generated contents note: Preface -- About the Editors -- About the Book -- List of Contributors -- Section1: Introduction -- Chapter 1 Quantitative modeling in toxicology: An introduction -- Melvin E. Andersen and Kannan Krishnan -- Section2: Physiologically-based toxicokinetic and pharmacokinetic )PBPK( modeling -- Chapter 2 PBPK modeling: a primer -- Kannan Krishnan, George Loizou, Martin Spendiff, John Lipscomb and Melvin E. Andersen -- Chapter 3 Pharmacokinetic modeling with Manganese - An essential element -- Andy Nong, Michael Taylor, Miyoung Yoon, and Melvin E. Andersen -- Chapter 4 Physiologically-based modeling of pharmacokinetic interactions in chemical mixtures -- Sami Haddad, Robert Tardif, Jonathan Boyd, and Kannan Krishnan -- Chapter 5 Physiological Parameters and Databases for PBPK Modeling -- Douglas O. Johns, Elizabeth Oesterling Owens, Chad M. Thompson, Babasaheb Sonawane, Dale Hattis and Kannan Krishnan -- Section3: Modeling toxicant-target interactions -- Chapter 6 Modeling cholinesterase Inhibition -- Charles Timchalk, Paul M. Hinderliter,and Torka S. Poet -- Chapter 7 Modeling of Protein Induction and dose-dependent hepatic sequestration -- Andy Nong and Melvin E. Andersen -- Chapter 8 Bistable Signaling Motifs and Cell Fate Decisions -- Sudin Bhattacharya, Qiang Zhang, and Melvin E. Andersen M.E. -- Chapter 9 Ultrasensitive Response Motifs in Biochemical Networks -- Qiang Zhang, Sudin Bhattacharya, Courtney G. Woods, and Melvin E. Andersen -- Chapter 01 Gene and Protein Expression - Modeling Nested Motifs in Cellular and Tissue Response Networks -- Melvin E. Andersen, Qiang Zhang, and Sudin Bhattacharya --

Mathematical models ، Toxicology

TI

AU Krishnan, Kannan 1961-

AU Andersen, Melvin E