۱۷۰۵۷پ
per
تعیین بیان گیرنده های H۱ و H۲ هیستامینی در هسته استریاتوم مغز موش های صحرایی سالم با تکنیک ایمونوهیستوشیمی و بررسی اثر تجویز محیطی و داخل استریاتومی آنتاگونیست های این گیرنده ها در پردازش درد نوروپاتیک
/رضا حضرتی
: دامپزشکی
، ۱۳۹۵
چاپی
دکتری
دکترای حرفه‌ای دامپزشکی
۱۳۹۵/۰۴/۰۳
تبریز
.noitpecrep niap lartnec ni elor yradnoces sah dna metsys noitomocol fo gnitaluger ni elor tnatropmi a sah mutairtS .nematup dna etaduac deman ielcun owt fo edam si hcihw ailgnag lasab niarb fo strap tnatropmi eht fo eno si mutairtS
.ve rats were doneg/site, naltrexone 2 and 4 g/site, chlorpheniramine 1.25 and 2.5 g/site and ranitidine 1.25 and 2.5g/site, chlorpheniramine and histamine 2.5 and 1 g/site respectively, ranitidine and histamine 2.5 and 1g/site respectively, naltrexone and histamine 4 and 1 g/site respectively) were injected and thermal place preference and mechanical allodynia were evaluated.Immunohistochemistry staining was done for H1, H2 and c-Fos expression in striatum and presentation were varifyed. Following to chronic peripheral injection of anti histamins and gabapentin, pain threshold was increased after chlorpheniramine and ranitidine (15 mg/kg) and gabapentin (100 mg/kg) injections. Licking and biting behavior were alleviated after chlorphenir amine (5 and 15 mg/kg) and ranitidine (15 mg/kg) and gabapentin (100 mg/kg), however, just gabapentin (100 mg/kg) could decrease the fliching behavior. Pain was significantly decreased following to chlorpheniramine (15 mg/kg) and ranitidine (5 and 5 mg/kg) and gabapentin (100 mg/kg) in DPT test. Intra striatum injection of histamine (0.75 and 1 g) were decreased pain behavior in Von Frey and DPT tests, while all 3 dosage of histamine (0.5, 0.75 and 1 g) could alleviate pain behavior in acetone test. Pretreatments with chlorpheniramine and naltrexone could not prevented histamine induced antinociception, while ranitidine (2.5 ?g) alleviated histamine (1 ?g)-induced antinociception. These results indicated that activation of brain neuronal histamine at the levels of striatum produced antinociception via histamine H2 receptors activation. On the other hand, peripheral histamine could induce nociception in the neuropathic animal via activation of its H1 and H2 receptors
.detaulave erew ecnereferp ecalp lamreht dna ainydolla dloc dna lacinahcem ni stsinogatna eseht fo tceffe eht dna )syad 13( star )TNT( detcesnart evren laibit eht otni yllacinorhc detcejni erew )PI ,gk/gm 51 dna 5 eniditinar dna gk/gm 51 dna 5 enimarinehprolhC( stsinogatna 2H dna 1H ,pets dnoces eht nI
حضرتی، رضا
dna ۵۷.۰ ,۵.۰ enimatsih ,stsinogatna ۲H dna ۱H dna star TNT fo mutairts eht otni detnalpmi erew yllaretalib salunnac cinorhc ,pets driht eht nI ۱گ.Neuropathic pain is a kind of chronic pain which causes mechanical and thermal allodynia and is followed by movement and psychiatric disorders. Neuropathic pain unlike other kind of pain isn't necessarily alarming people about possible irritation and is persistence to common antinociceptive drugs. This kind of pain can occur following mechanical trauma to nervous system, chemotherapy, diabetes, different viruse infection and alcoholism
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