عنوان

بررسی همراهی پلی مورفیسم ژن ‮‭CFI‬با بیماریتحلیل ماکولای وابسته به سن ‮‭(AMD)‬در سه منطقه ایران

‮‭ized by progressive degeneration of the RPE and secondary photoreceptor loss, resulting in visual loss. Etiological research suggests that AMD is a complex disease, caused by the interactions of several genetic and environmental factors. Polymorphisms in genes encoding the alternative complement pathway, complement factor I (CFI), are associated with the risk for AMD. The purpose of this investigation was studying of CFI p.Gly۱۱۹Arg polymorphism with Age-related macular degeneration (AMD) in three regions of IRAN. Materials&methods:In this case-control study, the association of p.Gly۱۱۹Arg polymorphism in CFI gene was investigated in ۲۷۴ patients suffering from AMD and ۱۷۶ healthy age, sex and ethnicity matched unrelated people as control group. Both of the case and control groups were originated from three regions of IRAN(Gounabad, Tabriz,Tehran).Genotypes of both groups were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). Results: Investigation of the association of p.Gly۱۱۹Argpolymorphism in CFI gene with AMD showed that there are statistically significant differences between patients and controls in genotype and allele frequencies of this polymorphism in the Tehran population (P<۰/۰۵).It is notable that, when combined population of Tehran and Tabriz the association of p.Gly۱۱۹Argpolymorphism in CFI gene with AMD just in genotype (TT) was observed. Conclusion:In the overall analysis indicates that p.Gly۱۱۹Argpolymorphism of the CFIgene is not related to the susceptibility to AMD in three regions of IRAN‬ص‍‮‭Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world and is character‬