Includes bibliographical references and index. Ch. 10. Vibrational isotope effects in hydrogen bonds / Zofia Mielke and Lurjan Sobczyk -- Ch. 11. Isotope selective infrared spectroscopy and intramolecular dynamics / Michael Hippler and Martin Quack -- Ch. 12. Nonmass-dependent isotope effects / Ralph E. Weston, Jr. -- Ch. 13. Isotope effects in the atmosphere / Etienne Roth, Rene Letolle, C. M. Stevens and Francois Robert -- Ch. 14. Isotope effects for exotic nuclei / Olle Matsson -- Ch. 15. Muonium - an ultra-light isotope of hydrogen / Emil Roduner -- Ch. 16. kinetic isotope effect in the photo-dissociation reaction of excited-state acids in aqueous solutions / Ehud Pines -- Ch. 17. role of an internal-return mechanism on measured isotope effects / Heinz F. Koch -- Ch. 18. Vibrationally enhanced tunneling and kinetic isotope effects in enzymatic reactions / Steven D. Schwartz -- Ch. 19. Kinetic isotope effects for proton-coupled electron transfer reactions / Sharon Hammes-Schiffer --
"The book describes the measurement of kinetic, equilibrium, and anharmonic isotope effects as well as basic theories, including gas phase, simple condensed phase, small molecule studies, and applications of the Bigeleisen-Mayer theory before describing how isotopes affect molecular geometries, chemical bond breaking, formation and chemical dynamics, and hydrogen transfer. It explores novel, mass-independent isotope effects and problems encountered in hydrogen transfer, tunneling, and exchange. Authors also discuss isotope effects in organic and organometallic reactions and complex enzyme reactions, while a unique chapter explores water isotope effects under pressure." "Written by internationally recognized researchers from 13 countries, Isotope Effects in Chemistry and Biology brings together a wide scope of different perspectives and practical developments and applications into a comprehensive reference of isotope effects that reflect the most current state of the art."--BOOK JACKET.
Ch. 34. Isotope effects from partitioning of intermediates in enzyme-catalyzed hydroxylation reactions / Paul F. Fitzpatrick -- Ch. 35. Chlorine kinetic isotope effects on biological systems / Piotr Paneth -- Ch. 36. Nucleophile isotope effects / Vernon E. Anderson, Adam G. Cassano and Michael E. Harris -- Ch. 37. Enzyme mechanisms from isotope effects / W. Wallace Cleland -- Ch. 38. Catalysis and regulation in the soluble methane monooxygenase system : applications of isotopes and isotope effects / John D. Lipscomb -- Ch. 39. Secondary isotope effects / Alvan C. Hengge -- Ch. 40. Isotope effects in the characterization of low barrier hydrogen bonds / Perry A. Frey -- Ch. 41. Theory and practice of solvent isotope effects / Daniel M. Quinn -- Ch. 42. Enzymatic binding isotope effects and the interaction of glucose with hexokinase / Brett E. Lewis and Vern L. Schramm.
Ch. 20. Kinetic isotope effects in multiple proton transfer / Zorka Smedarchina, Willem Siebrand and Antonio Fernandez-Ramos -- Ch. 21. Interpretation of primary kinetic isotope effects for adiabatic and nonadiabatic proton-transfer reactions in a polar environment / Philip M. Kiefer and James T. Hynes -- Ch. 22. Variational transition-state theory and multidimensional tunneling for simple and complex reactions in the gas phase, solids, liquids, and enzymes / Donald G. Truhlar -- Ch. 23. Computer simulations of isotope effects in enzyme catalysis / Arieh Warshel, Mats H. M. Olsson and Jordi Villa-Freixa -- Ch. 24. Oxygen-18 isotope effects as a probe of enzymatic activation of molecular oxygen / Justine P. Roth and Judith P. Klinman -- Ch. 25. Solution and computational studies of kinetic isotope effects in flavoprotein and quinoprotein catalyzed substrate oxidations as probes of enzymic hydrogen tunneling and mechanism / Jaswir Basran, Laura Masgrau, Michael J. Sutcliffe and Nigel S. Scrutton -- Ch. 26. Proton transfer and proton conductivity in condensed matter environment / Alexander M. Kuznetsov and Jens Ulstrup -- Ch. 27. Mechanisms of CH-bond cleavage catalyzed by enzymes / Willem Siebrand and Zorka Smedarchina -- Ch. 28. Kinetic isotope effects as probes for hydrogen tunneling in enzyme catalysis / Amnon Kohen -- Ch. 29. Hydrogen bonds, transition-state stabilization, and enzyme catalysis / Richard L. Schowen -- Ch. 30. Substrate and pH dependence of isotope effects in enzyme catalyzed reactions / William E. Karsten and Paul F. Cook -- Ch. 31. Catalysis by alcohol dehydrogenases / Bryce V. Plapp -- Ch. 32. Effects of high hydrostatic pressure on isotope effects / Dexter B. Northrop -- Ch. 33. Solvent hydrogen isotope effects in catalysis by carbonic anhydrase : proton transfer through intervening water molecules / David N. Silverman and Ileana Elder --
Ch. 1. Theoretical basis of isotope effects from an autobiographical perspective / Jacob Bigeleisen -- Ch. 2. Enrichment of isotopes / Takanobu Ishida and Yasuhiko Fujii -- Ch. 3. Comments on selected topics in isotope theoretical chemistry / Max Wolfsberg -- Ch. 4. Condensed matter isotope effects / W. Alexander Van Hook -- Ch. 5. Anharmonicities, isotopes, and IR and NMR properties of hydrogen-bonded complexes / Janet E. Del Bene -- Ch. 6. Isotope effects on hydrogen-bond symmetrization in ice and strong acids at high pressure / Katsutoshi Aoki -- Ch. 7. Hydrogen bond isotope effects studied by NMR / Hans-Heinrich Limbach, Gleb S. Denisov and Nikolai S. Golubev -- Ch. 8. Isotope effects and symmetry of hydrogen bonds in solution : single- and double-well potential / Jonathan S. Lau and Charles L. Perrin -- Ch. 9. NMR studies of isotope effects of compounds with intramolecular hydrogen bonds / Paul Erik Hansen --