Recent advances in the synthesis of morphine and related alkaloids / Noritaka Chida -- Opioids in preclinical and clinical trials / Hiroshi Nagase and Hideaki Fujii -- Synthesis of 14-alkoxymorphinan derivatives and their pharmacological actions / Helmut Schmidhammer and Mariana Spetea -- 14-amino-4,5-epoxymorphinan derivatives and their pharmacological actions / John W. Lewis and Stephen M. Husbands -- Nonpeptidic delta opioid agonists and antagonists of the diarylmethylpiperazine class: What have we Learned? / Silvia N. Calderon -- Synthesis of neoclerodane diterpenes and their pharmacological effects / Kimberly M. Lovell ... [et al.] -- Synthesis of novel basic skeletons derived from naltrexone / Hiroshi Nagase and Hideaki Fujii -- Twin and triplet drugs in opioid research / Hideaki Fujii -- 3D-pharmacophore identification for [kappa]-opioid agonists using ligand-based drug-design techniques / Noriyuki Yamaotsu and Shuichi Hirono.