9780470293423 (cloth)
IR
E-3921
انگلیسی
IR
BACE
[Book]
:lead target for orchestrated therapy of Alzheimer's disease
/ edited by Varghese John
Hoboken, N.J.
: John Wiley & Sons
, 2010.
xvi, 250 p., [16] p. of plates , ill. (some col.) , 25 cm.
Print
Includes bibliographical references and index.
BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo -- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha -- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski -- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott -- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig -- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli -- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head -- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont -- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu -- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.]
Alzheimer's disease, Chemotherapy
Aspartic proteinases, Inhibitors, Therapeutic use
Amyloid beta-protein precursor
Alzheimer Disease, drug therapy
Amyloid Precursor Protein Secretases, pharmacology
Amyloid Precursor Protein Secretases, therapeutic use
RC523
.
B24
2010
John, Varghese,1958-
ایران
BACE lead target for orchestrated therapy of Alzheimer's disease edited by Varghese John
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