عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
TLpq2385707470
انگلیسی
The Impact of Strength and Range of Motion on Loss of Ambulation and Functional Change Measures in Boys with DMD
[Thesis]
Duong, Tina
Canbek, Jennifer
Nova Southeastern University
2020
174
P.T.P.
Nova Southeastern University
2020
Duchenne muscular dystrophy (DMD) is an x-linked lethal progressive disorder affecting boys who are typically diagnosed due to motor delays or weakness. Key features include loss of motor function throughout the lifetime resulting in early mortality from cardiopulmonary complications in the late 2nd and 3rd decades of life. Rates of progression are variable yet sequential due to a typical pattern of motor weakness that occurs from proximal to distal muscle groups. Current standards of care include contracture management and Glucocorticosteroids (GC). Timed function tests have been used to understand and predict loss of functional milestones such as walking, getting off the ground and going upstairs. This study will describe contracture development; associated strength loss and its effect on function for boys with DMD. With differing rates of decline in boys with DMD, this study will also determine minimal clinical important difference (MCID) based on annual progression rates of 3 critical timed function tests (supine to stand, climb 4 stairs and 10meter walk test).
Contractures
Duchenne
MCID
Muscular dystrophy
Natural history
Timed tests
Canbek, Jennifer
Duong, Tina
مطالعه متن کتاب p
[Thesis]
276903
a
Y
