عنوان
پدید آورنده
موضوع
رده
کتابخانه
محل استقرار
TLpq2164266972
انگلیسی
Studies of Stroke-Associated Risk Factor Genes in Apical Periodontitis
[Thesis]
Rizzo, Gabriella
Letra, Ariadne
The University of Texas School of Dentistry at Houston
2019
57
M.Sc.D.
The University of Texas School of Dentistry at Houston
2019
Introduction: Apical periodontitis (AP) and cardiovascular disease (CVD) share endothelial inflammatory dysfunction as part of their etiology and multiple studies have suggested that an association exists between these conditions. Cerebrovascular disease (stroke) results from some of the same events as CVD, with hypertension being the most robust risk factor for stroke. We have previously reported on the association between hypertension and AP using epidemiologic and genetic approaches. In this study, we investigated the association between AP and stroke in a case-control population with and without AP. Methods: Clinical data and DNA samples from patients with (n=229) and without AP (n=213) recruited at the University of Texas School of Dentistry at Houston Endodontic Clinic were used for this study. Six single nucleotide polymorphism (SNPs) in stroke-associated risk factor genes were selected for genotyping our study population using Taqman chemistry in real time PCR. Data analysis was performed using chi-square and Fisher Exact tests as implemented in PLINK Software. P ≤ 0.05 indicated statistical difference between groups. Results: No significant genetic associations were found between the investigated polymorphisms in stroke risk factor genes and AP (P > 0.05). Conclusion: Within the limitations of this study, no association was found between stroke-related genes and AP. Studies with larger sample sizes and/or different genes should be performed to elucidate if potential correlations between these two conditions indeed exist.
Dentistry
Epidemiology
Physiology
Public health
Letra, Ariadne
Rizzo, Gabriella
مطالعه متن کتاب p
[Thesis]
276903
a
Y
