عنوان

Extracellular matrix and the liver :

0080531504

012525251X

1281037729

6611037721

9780080531502

9780125252515

9781281037725

9786611037727

b795632

Extracellular matrix and the liver :

[Book]

approach to gene therapy /

edited by Isao Okazaki [and others].

Boston :

Academic Press,

©2003.

1 online resource (xxi, 467 pages) :

illustrations

Includes bibliographical references and index.

New Insights into the Extracellular Matrix. -- Dynamic Regulation of Basement Membrane Collagen IV Gene Expression in Malignant Tumors. -- Regulation of Phenotypes of Human AortaEndothelial Cells and Smooth Muscle Cells in Culture by Type IV Collage Aggregates. -- Functions of Proteoglycan/Glycosaminoglycan in Liver; SPARC, A Matricellular Protein that Regulates Cell-Matrix Interaction: Implications for Vascular and Connective Tissue Biology. -- Cells Responsible for ECM Production in the Liver. Different Hepatic Cell Populations of the Fibroblast Lineage with Fibrogenic Potential. -- Role of Sinusoidal Endothelial Cells in Liver Inflammation and Repair. -- Molecular Mechanism of Stellate Cell Activation and ECM Remodeling. -- Role of Histone Deacetylases in Transcriptional Control of the Hepatic Stellate Cell Phenotype. Knockout Mice of Matrix Metalloproteinase Genes. Stem Cells Expressing MMP-13 mRNA Appear During Regression Reversal of Hepatic Cirrhosis.

0

Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discusses new strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapy approaches. The chapters are divided into six sections as follows: * Basic Science of Extracellular Matrix * Cells Responsible for Extracellular Matrix Production * Activation Mechanism of Hepatic Cells and Signal Transduction * Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors * Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases * New Strategies for the treatment of Liver Cirrhosis Key Features * Discusses the possibility of gene therapy for liver cirrhosis * Includes information on new aspects of hepatic stellate cells * Written by top experts in basic science and clinical hepatology.

Elsevier Science & Technology

90519:90519

Extracellular matrix and the liver.

9780125252515

Extracellular matrix.

Liver-- Cirrhosis-- Gene therapy.

Liver-- Cirrhosis-- Treatment.

Extracellular Matrix-- genetics, Congresses.

Liver Cirrhosis-- pathology, Congresses.

Liver Cirrhosis-- therapy, Congresses.

Extracellular matrix.

Liver-- Cirrhosis-- Treatment.

Okazaki, Isao.

International Conference on New Strategies for the Treatment of Liver Cirrhosis(2001 :, Tokyo, Japan)

20201207083806.0

pn

[Book]

Y