normal processes and the effects of alcohol and nicotine /
edited by Michael W. Miller.
New York :
Oxford University Press,
2006.
xv, 404 pages :
illustrations ;
26 cm
Includes bibliographical references and index.
Early exposure to ethanol affects the proliferation of neuronal precursors / Michael W. Miller -- Effects of ethanol on the regulation of cell cycle in neural stem cells / W. Michael Zawada, Mita Das -- Mechanisms of ethanol-induced alterations in neuronal migration / Julie A. Siegenthaler, Michael W. Miller -- Effects of ethanol on mechanisms regulating neuronal process outgrowth / Tara A. Lindsley -- Neuronal survival is compromised by ethanol: extracellular mediators / Michael W. Miller, Marla B. Bruns, Paula L. Hoffman -- Intracellular events in ethanol-induced neuronal death / Sandra M. Mooney, Michael W. Miller, George I. Henderson -- Neural crest and developmental exposure to ethanol / Susan M. Smith, Katherine A. Debelak-Kragtorp.
Glial targets of developmental exposure to ethanol / Consuelo Guerri, Gemma Rubert, Maria Pasqual -- Tobacco use during pregnancy: epidemiology and effects on offspring / Jennifer A. Willford, Nancy L. Day, Marie D. Cornelius -- Prenatal nicotine exposure and animal behavior / Brenda M. Elliott, Neil E. Grunberg -- Neuronal receptors for nicotine: functional diversity and developmental changes / Huibert D. Mansvelder, Lorna W. Role -- Neural precursors as preferential targets for drug abuse: long term consequences and latent susceptibility to central nervous system disorders / Kurt F. Hauser [and others] -- Nicotinic receptor regulation of developing catecholamine systems / Frances M. Leslie [and others].
Models of neurotoxicity provide unique insight into normal development / Michael W. Miller -- Cell proliferation / Bernhard Suter, Pradeep G. Bhide -- Neuronal migration / Huaiyu Hu -- Neuronal differentiation: from axons to synapses / C. David Mintz [and others] -- Cell death / Stevens K. Rehen, Jerold J.M. Chun -- Intracellular pathways of neuronal death / Sandra M. Mooney, George I. Henderson -- Developmental disorders and evolutionary expectations: mechanisms of resilience / Barbara L. Finlay, Jeremy C. Yost, Desmond T. Cheung -- Prenatal alcohol exposure and human development / Claire D. Coles -- Influence of alcohol on the structure of the developing human brain / Susanna L. Fryer [and others] -- Prenatal ethanol exposure and fetal programming: implications for endocrine and immune development and long-term health / Joanna H. Sliwowska, Xingqi Zhang, Joanne Weinberg.
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Covers both normal development of the nervous system and how early exposure to alcohol and nicotine interferes with this development. The developing nervous system is highly dynamic and vulnerable to genetic and epigenetic factors that can be additive or synergistic. Disruption of normal brain development leads to an array of developmental disorders. The book is divided into three parts. The first describes neural ontogeny in the normal brain. The second and third deal with the consequences of early exposure to alcohol and nicotine. Though there are similarities in the effects of these two toxins, there are also intriguing differences.