Metabolic response to starvation, stress, and sepsis -- Pathophysiology of fluid and electrolyte disorders -- Surgical nutrition -- The immune system and the immunocompromised patient -- Physiologic basis of transplantation -- Surgical infection: principles of management and antibiotic usage -- Hemostasis and thrombosis in the surgical patient -- Pathophysiology of shock -- Neoplastic disease: pathophysiology and rationale for treatment -- The physiology of anesthesia and pain -- Sepsis and the syndrome of multiple organ failure -- Application of cellular and molecular biology in modern surgical practice -- Physiologic principles in preparing patients for surgery -- Physiologic dysfunction of the esophagus -- Gastric physiology and acid-peptic disorders -- Physiology of digestion and absorption -- Circulation and vascular disorders of the splanchnic vascular bed -- Inflammatory disorders of the small bowel and colon -- Hepatic physiology -- Portal hypertension -- Calculous disease of the gallbladder and common bile duct -- Normal exocrine function and inflammatory diseases of the pancreas -- The jaundiced patient -- The spleen -- Gastrointestinal hemorrhage -- The anatomy, physiology, and differential diagnosis of acute abdominal pain -- Neoplastic disorders of the gastrointestinal tract -- Mechanical disorders of the stomach, duodenum, and intestine -- Physiologic derangements of the anorectum and the defecatory pelvic floor -- Derrangement in gastrointestinal function secondary to previous surgery -- Pathobiology of surgically relevant pulmonary disease -- Normal cardiac function -- Heart failure and resuscitation -- Mechanical support for the failing heart: current physiologic concepts of management -- Congenital heart lesions -- Acquired cardiac disorders -- Urine formation: from normal physiology to florid kidney failure -- Urinary tract obstruction -- Neurogenic lower urinary tract dysfunction -- Pathophysiology and management of head injury -- Spinal cord injury -- Injuries to peripheal nerves -- Physiology of arterial, venous, and lymphatic flow -- Aorta and arterial disease of the lower extremity -- Cerebrovascular disease and upper-extremity vascular disease -- Venous and lymphatic abnormalities of the limbs -- Diseases of the thoracic aorta -- Secondary hypertension: pathophysiology and operative treatment -- Calcium and phosphorus metabolism and the parathyroid gland -- Pituitary dysfunction -- Adrenal glands -- The thyroid gland -- Endocrine pancreas -- Multiple endocrine neoplasia; type 1 and 2 -- The biology of wound healing -- Breast: physiology considerations in normal, benign, and neoplastic states -- Hernias of the abdominal wall and its contents -- Pathophysiology of thermal injury -- Physiologic problems in the pediatric surgical patient -- Physiologic considerations in the elderly surgical patient -- Surgery for morbid obesity.
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Completely updated with contributions by world leaders in surgery and the surgery specialties, this reference assists surgeons in the diagnosis and treatment of patients by considering disease as a derangement of normal physiology, thus allowing the surgeon to correlate the appropriate use of laboratory and radiologic modalities. Arranged according to specific organ systems, the book is easily accessible and reflects the impact that scientific discoveries and technical advances have had on our understanding of the physiologic processes in surgical patients.