The growth of knowledge about air, breathing, and circulation as they relate to high altitude / Charles S. Houston -- The atmosphere / John B. West -- The people / Susan Niermeyer, Stacy Zamudio, and Lorna G. Moore -- Cellular and molecular mechanisms of O₂ sensing with special reference to the carotid body / Sukhamay Lahiri and Neil S. Cherniack -- Molecular/Metabolic defense and rescue mechanisms for surviving oxygen lack : from genes to pathways / Peter W. Hochachka -- Control of breathing at high altitude / Curtis A. Smith, Jerome A. Dempsey, and Thomas F. Hornbein -- Mechanisms of breathing / Joseph Milic-Emili, Bengt Kayser, and Henry Gautier -- Gas exchange / Peter D. Wagner -- The cardiovascular system at high altitude : heart and systemic circulation / Eugene E. Wolfel and Benjamin D. Levine -- The pulmonary circulation at high altitude / John T. Reeves and Kurt R. Stenmark -- Cerebral circulation at high altitude / John W. Severinghaus -- The high-altitude brain / Marcus E. Raichle and Thomas F. Hornbein -- Autonomic nervous system / Douglas R. Seals, Pamela Parker Jones, and Kevin P. Davy -- The effects of altitude on skeletal muscle / Howard J. Green and John R. Sutton -- Blood / Robert F. Grover and Peter Bärtsch -- Renal function and fluid homeostasis / Erik R. Swenson -- Metabolic response of lowlanders to high-altitude exposure : malnutrition versus the effect of hypoxia / George A. Brooks and Gail E. Butterfield -- The endocrine system / Jean-Paul Richalet -- High altitude and human immune responsiveness / Richard T. Meeham, Peter N. Uchakin, and Clarence F. Sams -- Exercise and hypoxia : performance, limits, and training / Robert Roach and Bengt Kayser -- Sleep / John V. Weil and David P. White -- Acute mountain sickness and high-altitude cerebral edema / Peter Bärtsch and Robert Roach (with Diana Depla) -- High-altitude pulmonary edema / Robert B. Schoene, Herbert N. Hultgren, and Erik R. Swenson -- Chronic mountain sickness in Andeans / Carlos C. Monge, Fabiola Léon-Velarde, and Alberto Arrigui -- High altitude and common medical conditions / Peter H. Hackett.