Yeast prions : evolution of the prion concept / Reed B. Wickner [and others] -- The genetic control of the formation and propagation of the [PSI+] prion of yeast / Mick F. Tuite and Brian S. Cox -- A short history of small s : a prion of the fungus Podospora anserina / Sven J. Saupe -- Prion-prion interactions / Irina L. Derkatch and Susan W. Liebman -- Prion stability / Brian S. Cox, Lee Byrne, and Mick F. Tuite -- Prion and nonprion amyloids : a comparison inspired by the yeast sup35 protein / Vitaly V. Kushnirov [and others] -- Chaperone effects on prion and nonprion aggregates / Eugene G. Rikhvanov, Nina V. Romanova and Yury O. Chernoff -- Biological roles of prion domains / Sergey G. Inge-Vechtomov, Galina A. Zhouravleva and Yury O. Chernoff -- Preformed cell structure and cell heredity / Janine Beisson -- Centriole inheritance / Patricia G. Wilson.
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This book covers a topic that has been neglected for years and has returned to the spotlight only recently. Until the genetic role of DNA was firmly established, many researchers suspected that proteins, rather than nucleic acids, could be carriers of heritable information. However, these models were completely forgotten with the triumphal march of the double helix and the development of a central dogma postulating that information flow occurs strictly from DNA, through RNA, to protein, making it seemingly impossible for the proteins to possess a coding potential. Proteins were downgraded to t.