Foreword / Thomas A. Luger -- Part I. Clinical Classification of Itch -- 1. Definitions of Itch / Gil Yosipovitch and Malcolm W. Greaves -- Part II. Basic Mechanisms of Itch -- 2. Neurophysiologic Basis of Itch / Martin Schmelz and Hermann O. Handwerker -- 3. Pain and Itch / Martin Schmelz and Hermann O. Handwerker -- 4. Central Neural Mechanisms of Itch / David Andrew and A.D. Craig -- 5. Animal Models of Itch : Scratching Away at the Problem / Earl Carstens and Yasushi Kuraishi -- 6. Histamine-Induced Discriminative and Affective Responses Revealed by Functional MRI 51 / Francis McGlone [and others] -- 7. Central Nervous System Imaging of Itch with PET 63 / Ulf Darsow, Alexander Drzezga, and Johannes Ring -- 8. Skin Nerve Anatomy : Neuropeptide Distribution and Its Relationship to Itch / Dieter Metze -- 9. Substance P and Itch / Tsugunobu Andoh and Yasushi Kuraishi -- 10. Peripheral Opiate Receptor System in Human Epidermis and Itch / Paul Lorenz Bigliardi and Mei Bigliardi-Qi -- 11. Antipruritic Activity of a Novel K-Opioid Receptor Agonist, TRK-820 / Jun Utsumi [and others] -- 12. Putative Role of Cannabinoids in Experimentally Induced Itch and Inflammation in Human Skin / Roman Rukwied [and others] -- 13. Itch Models in Animals, with Special Emphasis on the Serotonin Model in Rats / Jens Schiersing Thomsen -- 14. Human Itch Models, with Special Emphasis on Itch in SLS-Inflamed and Normal Skin / Jens Schiersing Thomsen -- Part III. Evaluation of Patients with Itch -- 15. Microdialysis in Itch Research / Martin Schmelz -- 16. Measuring Nocturnal Scratching in Atopic Dermatitits / Toshiya Ebata -- 17. Itch Questionnaires as Tools for Itch Evaluation / Gil Yosipovitch -- Part IV. Epidemiology and Characteristics of Itch -- 18. Epidemiology of Itching in Skin and Systemic Diseases / Gil Yosipovitch -- 19. Uremic Pruritus : New Perspectives and Insights from Recent Trials / Thomas Mettang, Dominik Mark Alscher, and Christiane Pauli-Magnus -- 20. Pruritus Complicating Liver Disease / Nora V. Bergasa and E. Anthony Jones -- 21. Itch in HIV-Infected Patients / Maria I. Duque, Gil Yosipovitch, and P. Samuel Pegram -- 22. Neuropathic Pruritus / Gil Yosipovitch [and others] -- 23. Clinical Features of Itch in Atopic Eczema / Ulf Darsow and Johannes Ring -- 24. Postburn Itch / Robert D. Nelson -- 25. Pruritus in Lichen Simplex Chronicus and Lichen Amyloidosis / Yung-Hian Leow and Gil Yosipovitch -- Part V. Treatment of Itch -- 26. Treatment of Pruritus in Internal and Dermatological Diseases with Opioid Receptor Antagonists / Sonja Stander and Dieter Metze -- 27. Prospects for a Novel K-Opioid Receptor Agonist, TRK-820, in Uremic Pruritus / Hiroo Kumagai [and others] -- 28. Treatment of Pruritic Skin Diseases with Topical Capsaicin / Sonja Stander and Dieter Metze -- 29. Mechanistic and Clinical Assessment of Zangrado, an Extract of the Amazonian Ethnomedicine Sangre de Grado, for the Treatment of Itch / Mark J.S. Miller [and others] -- 30. Reduction in Itch Severity with Topical Immunomodulators : A New Approach for Patients with Inflammatory Disease / Alan B. Fleischer, Jr. -- 31. 5-HT3 Receptor Antagonists as Antipruritics / Elke Weisshaar -- 32. Cutaneous Nerve Stimulation in Treatment of Localized Itch / Joanna Wallengren -- Part VI. Social and Psychological Aspects -- 33. Psychosomatic Aspects of Pruritus / Uwe Gieler [and others] -- 34. On Psychological Factors Affecting Reports of Itch Perception / Elia E. Psouni -- 35. Itching as a Focus of Mental Disturbance / Yuval Melamed and Gil Yosipovitch.
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This reference presents new concepts in the neurophysiology and central mechanisms of itch, animal models of itch, and processing of histamine itch in the human cerebral cortex. The text clarifies itch in systemic and skin disease, exploring renal itch, uremic pruritus, lichen amyloidosis and more.