Cover; Half-title; Title; Copyright; Addendum; Chapter 1: Structure and function of muscle fibers and motor units; References; Chapter 2: Myogenic precursor cells; References; Chapter 3: Biochemical and molecular basis of muscle disease; References; Section 2: Investigation of muscle disease; Chapter 4: Electrophysiological evaluation of suspected myopathy; References; Chapter 5: Histopathology and immunoanalysis of muscle; References; Chapter 6: Ultrastructural study of muscle; References; Chapter 7: Diagnostic imaging of muscle; References.
Section 3A: Description of muscle disease -- general aspectsReferences; Chapter 9: The principles of molecular therapies for muscle diseases; References; Chapter 10: Dystrophinopathies; References; Chapter 11: Muscular dystrophies presenting with proximal muscle weakness; Acknowledgments; References; Chapter 12: Dystrophic myopathies of early childhood onset (congenital muscular dystrophies); References; Chapter 13: The congenital myopathies; Acknowledgments; References; Chapter 14: Muscle diseases with prominent muscle contractures; References; Chapter 15: Facioscapulohumeral dystrophy.
Upregulation of MHC class I antigen on muscle fibers and formation of immunological synapses with the autoinvasive cytotoxic CD8+ T-cellsReferences; Chapter 23: Autoimmune and inherited disorders of neuromuscular transmission; Acknowledgment; References; Chapter 24: Endocrine and toxic myopathies; References; Chapter 25: Myofibrillar myopathies; References; Chapter 26: Hereditary inclusion body myopathies; Acknowledgments; References; Chapter 27: Other myopathies; References.
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"This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology is summarized. Combining essential new knowledge with the fundamentals of history-taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practising physicians and biomedical scientists concerned with muscle disease. Regular updates on the clinical and basic science aspects of muscle disease - written mainly by rising stars of myology - will be published on an accompanying website"--Provided by publisher.