Cover; List of contributors; Title; Copyright; Dedication; Contents; Preface; 1 Epidemiological and clinical aspects of human typhoid fever; 1.1 Introduction; 1.2 Salmonella enterica serovar Typhi; 1.3 Epidemiology of typhoid fever; 1.4 Pathophysiology of typhoid fever; 1.5 Clinical features of typhoid fever; 1.6 Diagnosis of typhoid fever; 1.7 Management of typhoid fever; 1.8 Control and prevention of typhoid fever; 1.9 Conclusions; 2 Antibiotic resistance in Salmonella infections; 2.1 Introduction; 2.2 Antibiotic resistance in S. enterica serovar Typhi.
2.3 Antibiotic resistance in enteric fevers other than typhoid2.4 Antibiotic resistance in non-typhoid Salmonella enteric serovars; 2.5 The causes of resistance; 2.6 Conclusions; 3 Host-specificity of Salmonella infections in animal species; 3.1 Introduction; 3.2 Salmonella infections of cattle; 3.3 Salmonella infections of pigs; 3.4 Salmonella infections of domestic fowl and other avian species; 3.5 What are the determinants of Salmonella serovar host-specificity?; 3.6 Do host-specific serovars use a strategy of stealth to cause systemic disease?
3.7 Dissemination of Salmonella to systemic tissues -- an evolutionary dead-end or an alternative means of inter-animal spread?3.8 Conclusions; 3.9 Acknowledgements; 4 Public health aspects of Salmonella enterica in food production; 4.1 Introduction and historical perspective; 4.2 Recent trends in S. enterica infections; 4.3 Human disease caused by S. enterica and vehicles for its transmission to humans; 4.4 Animal reservoirs of S. enterica infection; 4.5 Milk and milk products as vehicles of infection; 4.6 Meat and meat products and S. enterica.
4.7 Contamination of poultry meat with S. enterica4.8 Eggs and egg products as vehicles of infection and the S. enterica serovar Enteritidis pandemic; 4.9 The infectious dose of S. enterica; 4.10 Conclusions; 5 The Salmonella genome: a global view; 5.1 Introduction; 5.2 Full genome sequences facilitate the study of Salmonella; 5.3 Comparative genomics: old and new techniques; 5.4 In silico tools for comparative genomics; 5.5 Microarray technology as a tool for comparative genomics; 5.6 Sequenced Salmonella genomes as tools for comparative genomics.
5.7 In silico analysis of Salmonella genomes and comparisons between genome sequences5.8 Mobile genetic elements: plasmids and bacteriophages; 5.9 Fimbrial and pilus genes are highly variable between Salmonella genomes; 5.10 Analysis of Salmonella genomes based on microarray technology; 5.11 Genome sequences facilitate functional genomics; 5.12 Conclusions; 5.13 Acknowledgements; 6 Pathogenicity islands and virulence of Salmonella enterica; 6.1 Introduction; 6.2 Pathogenicity islands of Salmonella; 6.3 Salmonella Pathogenicity Island 1; 6.4 Salmonella Pathogenicity Island 2.
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Integrated view of clinical, molecular and immunological aspects of the biology of Salmonella enterica infections.