عنوان

Membrane transporters in drug discovery and development :

1607617005

9781607617006

1607616998

9781607616993

b753290

Membrane transporters in drug discovery and development :

[Book]

methods and protocols /

edited by Qing Yan.

[Clifton, N.J.] :

Humana,

©2010.

1 online resource (xiii, 363 pages) :

illustrations

Methods in molecular biology ;

Springer protocols

v. 637

Includes bibliographical references and index.

Membrane transporters and drug development : relevance to pharmacogenomics, nutrigenomics, epigenetics, and systems biology / Qing Yan -- Bioinformatics for transporter pharmacogenomics and systems biology : data integration and modeling with UML / Qing Yan -- Multidrug resistance : phylogenetic characterization of superfamilies of secondary carriers that include drug exporters / Ming Ren Yen [and others] -- Targeting drug transporters--combining in silico and in vitro approaches to predict in vivo / Praveen M. Bahadduri [and others] -- Methods to evaluate transporter activity in cancer / Takeo Nakanishi, Douglas D. Ross, and Keisuke Mitsuoka -- Analysis of expression of drug resistance-linked ABC transporters in cancer cells by quantitative RT-PCR / Anna Maria Calcagno and Suresh V. Ambudkar -- Fluorescence studies of drug binding and translocation by membrane transporters / Frances J. Sharom, Ronghua Liu, and Balpreet Vinepal -- A model for transport studies of the blood-brain barrier / Dennis J. Bobilya -- Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders / Falk W. Lohoff -- Equilibrium binding and transport by vesicular acetylcholine transporter / Parul Khare [and others] -- ABC transporters in ophthalmic disease / Corey Westerfeld -- Imaging of protein translocation in situ in skeletal muscle of living mice / Hans P.M.M. Lauritzen -- Glucose transporters in parasitic protozoa / Scott M. Landfear -- NMR studies of membrane proteins / Gabriel A. Cook and Stanley J. Opella -- Site-directed mutagenesis in the study of membrane transporters / Andra A. McKinzie, Renae M. Ryan, and Robert J. Vandenberg -- Xenopus laevis oocytes / Stefan Bröer -- Measurement of Intracellular pH / Frederick B. Loiselle and Joseph R. Casey -- Measurement of plasma membrane calcium-calmodulin-dependent ATPase (PMCA) activity / Tamer M.A. Mohamed [and others] -- Assessment of the contribution of the plasma membrane calcium ATPase, PMCA, calcium transporter to synapse function using patch clamp electrophysiology and fast calcium imaging / Chris J. Roome and Ruth M. Empson.

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Studies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular Biology series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.

Springer

978-1-60761-699-3

Membrane transporters in drug discovery and development.

1607616998

Carrier proteins.

Drugs-- Physiological transport.

Biological Transport-- drug effects.

Drug Carriers.

Drug Discovery-- methods.

Membrane Transport Proteins.

Carrier proteins.

Drugs-- Physiological transport.

MED071000

MMG

Yan, Qing,1971-

20201204124949.0

pn

[Book]

Y