contributions of computational approaches to elucidating macromolecular structure and function /
Committee on Computer-Assisted Modeling, Board on Basic Biology, Commission on Life Sciences, National Research Council.
Washington, D.C. :
National Academy Press,
1987.
1 online resource (x, 175 pages) :
illustrations
Includes bibliographical references (pages 160-175).
In much of biology, the search for understanding the relation between structure and function is now taking place at the macromolecular level. Proteins, nucleic acids, and polysaccharides are macromolecule--polymers formed from families of simpler subunits. Because of their size and complexity, the polymers are capable of both inter- and intramolecular interactions. These interactions confer upon the polymers distinctive three-dimensional shapes. These tertiary configurations, in turn, determine the function of the macromolecule. Computers have become so inextricably involved in empirical studies of three-dimensional macromolecular structure that mathematical modeling, or theory, and experimental approaches are interrelated aspects of a single enterprise.
Computer-assisted modeling.
Biochemistry-- Computer simulation.
Macromolecules-- Data processing.
Computer Simulation.
Macromolecular Substances.
Biochemistry-- Computer simulation.
Life Sciences / Molecular Biology.
Macromolecules-- Data processing.
SCIENCE-- Chemistry-- Organic.
SCIENCE.
SCI-- 013040
547
.
7/028/54
22
QD381
.
9
.
E4
.
C86
1987eb
National Research Council (U.S.)., Committee on Computer-Assisted Modeling.