Front Cover -- Advances in Clinical Chemistry, Volume 25 -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter 1. Ion-Selective Electrodes -- 1. Overview -- 2. An Introduction to Ion-Selective Electrodes (ISEs) -- 3. ISEs in Modern Clinical Chemistry Analyzers -- 4. Miniature and Micro-ISEs -- 5. ISE Devices for Biochemical Species -- 6. Future Prospects -- References -- Chapter 2. The Somatomedins: Insulin-Like Growth Factors -- 1. Introduction -- 2. Production, Properties, and Actions -- 3. Somatomedin Binding Proteins.
4. Receptors for Somatomedins -- 5. Analytical Methods -- 6. Circulating Levels Throughout Life -- 7. Circulating Levels in Disorders of Growth -- 8. Circulating Levels in Other Disease States -- 9. Concluding Remarks -- References -- Chapter 3. Synthetic Peptide Substrate Assays for Hemostasis Testing -- 1. Introduction -- 2. A Brief Review of Hemostasis -- 3. Natural Substrates versus Synthetic Substrates -- 4. Assay Design -- 5. Measurement of Specific Factors -- 6. Monitoring of Oral Anticoagulant Therapy -- 7. Monitoring of Heparin Therapy -- 8. Conclusions -- References.
5. Conditions Associated with a Deficiency of Folic Acid -- 6. Inborn Errors of Metabolism -- 7. Folate Metabolism and Renal Failure -- 8. Folate Deficiency during Intensive Therapy -- 9. Folate and Malignant Diseases -- 10. Other Causes of Disordered Folate Metabolism -- 11. Folate Nutrition in the Elderly -- 12. Toxicity of Folic Acid -- References -- Index.
Chapter 4. Bile Acids -- 1. Introduction -- 2. Physicochemical Properties of Bile Acids -- 3. The Biosynthesis of Bile Acids and Its Regulation -- 4. The Enterohepatic Circulation of Bile Acids -- 5. Physiological Functions of Bile Acids -- 6. The Biochemical Assay of Bile Acids -- 7. Measurement of Bile Acids in Clinic Tests -- 8. Gallstone Dissolution with Bile Acids -- References -- Chapter 5. Clinical Chemistry of Folic Acid -- 1. Introduction -- 2. Chemistry and Biochemistry -- 3. Methods of Measurement -- 4. Folate-Nutritional Requirements.