Sect. I. Basic principles. Allosteric modulation of receptor function / Stephen Daniels -- Characteristics of allosterism in drug action / Terry P. Kenakin -- Predicting dose-response curve behavior / David A. Hall -- Sect. II. Ionotropic receptors. Allosteric modulation of GABAa receptors / Hanns Möhler -- Allosteric interactions at the NMDA receptor channel complex / Manolo Mugnaini -- 5-HT3 receptors / Li Zhang and Sarah C.R. Lummis -- Nicotinic receptors / R.C. Hogg and D. Bertrand -- Sect. III. G-protein-coupled receptors. Allosteric modulation of G-protein-coupled receptors / Willem Soudijn, Ineke van Wijngaarden, and Ad P. Ijzerman -- Allosteric modulators of group III metabotropic glutamate receptors as novel therapeutics / Jesper Mosolff Mathiesen and M. Teresa Ramirez -- Allosteric modulation of GABAb receptors / Stephan Urwyler -- Allosteric interactions at GABAb and related G-protein-coupled receptors / David I.B. Kerr and Jennifer Ong -- Muscarinic receptors / Christian Tränkle -- [alpha]2-Adrenoceptors / Emma S.J. Robinson and Alan L. Hudson.
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Offering illustrations and tables in every chapter, this book extensively covers the principles of allosterism in reference to drug action and progresses to a detailed examination of individual ionotropic and G-protein coupled receptor systems. It helps those new to the subject understand the importance of allosterism.